Morphological and electrophysiological diversity and connectivity of principal neurons in the lateral and basal nuclei of the mouse amygdala

BLAa (Basolateral amygdalar nucleus, anterior part) MBA:303 projects to CEAm (Central amygdalar nucleus, medial part) MBA:559 · Mouse

Axon collaterals of in vivo filled BAa principal neurons were found in the medial division of the central amygdala.

Fig. 8E; Supplementary Fig. S8

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BLAa (Basolateral amygdalar nucleus, anterior part) MBA:303 projects to BLAp (Basolateral amygdalar nucleus, posterior part) MBA:311 · Mouse

Axons of reconstructed anterior basal principal neurons branched mainly locally and in the posterior basal subnucleus.

Fig. 8E

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AI (Agranular insular area) MBA:95 projects to BLAp (Basolateral amygdalar nucleus, posterior part) MBA:311 · Mouse

Cre-dependent anterograde labelling of glutamatergic insular cortex neurons showed axons innervating the DsRed-negative posterior basal subnucleus.

Fig. 3B; Supplementary Fig. S4

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BLAa (Basolateral amygdalar nucleus, anterior part) MBA:303 projects to CEAl (Central amygdalar nucleus, lateral part) MBA:551 · Mouse

After CEAl tracer injections, retrogradely labelled basal amygdala neurons were restricted to the BAp, and the DsRed-positive BAa lacked CEAl-projecting cells.

Fig. 6B

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BLAa (Basolateral amygdalar nucleus, anterior part) MBA:303 projects to PL (Prelimbic area) MBA:972 · Mouse

Retrograde tracer was injected into the prelimbic cortex. Labelled basal amygdala principal neurons lay almost exclusively in the anterior, DsRed-positive subnucleus.

Fig. 6A

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BLAa (Basolateral amygdalar nucleus, anterior part) MBA:303 projects to CEAl (Central amygdalar nucleus, lateral part) MBA:551 · Mouse

Reconstructed BAa principal neuron axons were absent from the lateral division of the central amygdala, consistent with the retrograde tracing results.

Fig. 8E; Supplementary Fig. S8

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LA (Lateral amygdalar nucleus) MBA:131 projects to HPF (Hippocampal formation) MBA:1089 · Mouse

vHipp/SUB retrograde injections labelled lateral amygdala neurons, with no spatial segregation between LA subnuclei.

Fig. 6C

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BLAp (Basolateral amygdalar nucleus, posterior part) MBA:311 projects to HPF (Hippocampal formation) MBA:1089 · Mouse

Retrograde tracer injected into the vHipp/SUB labelled projecting neurons in the posterior basal subnucleus as well as the anterior one.

Fig. 6C

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BLAa (Basolateral amygdalar nucleus, anterior part) MBA:303 projects to LA (Lateral amygdalar nucleus) MBA:131 · Mouse

Axon collaterals of reconstructed BAa principal neurons were also seen in the lateral amygdala.

Fig. 8; Supplementary Fig. S8

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LA glutamatergic principal neurons nt-659aayyts5 projects to AIp (Agranular insular area, posterior part) MBA:111 · Mouse

Anterior axon branches of reconstructed LAp principal neurons reached the posterior agranular insular cortex.

Fig. 8D

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LA (Lateral amygdalar nucleus) MBA:131 projects to CEAl (Central amygdalar nucleus, lateral part) MBA:551 · Mouse

CEAl retrograde tracer injections labelled neurons throughout the lateral amygdala, with no segregation between its subnuclei.

Fig. 6B

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BLAp (Basolateral amygdalar nucleus, posterior part) MBA:311 projects to TR (Postpiriform transition area) MBA:566 · Mouse

Axons of in vivo filled BAp principal neurons reached the amygdalo-piriform transition area.

Figs. 7F, 8F,G

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LA glutamatergic principal neurons nt-659aayyts5 projects to BLAp (Basolateral amygdalar nucleus, posterior part) MBA:311 · Mouse

Other reconstructed LAp principal neurons sent axons to the posterior basal subnucleus instead of the anterior one.

Fig. 8D; Supplementary Fig. S8

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LA glutamatergic principal neurons nt-659aayyts5 projects to CP (Caudoputamen) MBA:672 · Mouse

Single in vivo filled lateral amygdala principal neurons, from both the anterior and posterior subnuclei, had axons innervating the ventral caudoputamen.

Fig. 8B-D

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Isocortex MBA:315 projects to BLAp (Basolateral amygdalar nucleus, posterior part) MBA:311 · Mouse

In rostral and caudal segments of the basal nucleus, labelled glutamatergic mPFC axons reached both the BAa and the BAp, in a pattern complementary to insular afferents.

Fig. 3A; Supplementary Fig. S3

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BLAp (Basolateral amygdalar nucleus, posterior part) MBA:311 projects to LA (Lateral amygdalar nucleus) MBA:131 · Mouse

Axon collaterals of reconstructed BAp principal neurons were observed in the lateral amygdala.

Fig. 8; Supplementary Fig. S8

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BLAp (Basolateral amygdalar nucleus, posterior part) MBA:311 projects to BLAa (Basolateral amygdalar nucleus, anterior part) MBA:303 · Mouse

Reconstructed BAp principal neurons sent axons into the neighbouring anterior basal subnucleus.

Figs. 7F, 8F,G

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LA glutamatergic principal neurons nt-659aayyts5 projects to TR (Postpiriform transition area) MBA:566 · Mouse

Posterior axon branches of in vivo filled LAp principal neurons arborized in the amygdalo-piriform transition area.

Fig. 8D

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Isocortex MBA:315 projects to BLAa (Basolateral amygdalar nucleus, anterior part) MBA:303 · Mouse

Cre-dependent AAV injected into the mPFC of Vglut1-Cre mice labelled glutamatergic cortical axons. These axons innervated the DsRed-positive anterior basal subnucleus, and in medial sections they were the only afferents labelled there.

Fig. 3A; Supplementary Figs S3-S4

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BLAp (Basolateral amygdalar nucleus, posterior part) MBA:311 projects to CEAl (Central amygdalar nucleus, lateral part) MBA:551 · Mouse

Axon collaterals of in vivo filled posterior basal principal neurons were typically present in the lateral central amygdala, as well as in other CEA subdivisions.

Figs. 7F, 8F,G

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MTN (Midline group of the dorsal thalamus) MBA:571 projects to BLA (Basolateral amygdalar nucleus) MBA:295 · Mouse

After AAV5-CaMKII-eYFP was injected into the midline thalamus, labelled axons mainly targeted the basal amygdala. They covered both subnuclei, regardless of DsRed boundaries.

Fig. 3C; Supplementary Fig. S5

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LA glutamatergic principal neurons nt-659aayyts5 projects to BLAa (Basolateral amygdalar nucleus, anterior part) MBA:303 · Mouse

Some reconstructed posterior lateral amygdala principal neurons projected to the anterior basal subnucleus. LAa neurons also sent axons into the BA.

Fig. 8D; Supplementary Fig. S8

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BLAp (Basolateral amygdalar nucleus, posterior part) MBA:311 projects to HPF (Hippocampal formation) MBA:1089 · Mouse

Two juxtacellularly labelled BAp principal neurons branched extensively locally and sent axons to several parts of the hippocampal formation.

Supplementary Fig. S9

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LA glutamatergic principal neurons nt-659aayyts5 projects to CEA (Central amygdalar nucleus) MBA:536 · Mouse

Two juxtacellularly filled and reconstructed principal neurons in the anterior lateral amygdala sent axons into the central amygdala.

Fig. 8B,C

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AI (Agranular insular area) MBA:95 projects to BLAa (Basolateral amygdalar nucleus, anterior part) MBA:303 · Mouse

In rostral and caudal segments of the basal nucleus, labelled insular cortex axons targeted both BA subnuclei, including the BAa, complementary to mPFC axons.

Fig. 3B; Supplementary Fig. S4

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BLAp (Basolateral amygdalar nucleus, posterior part) MBA:311 projects to CEAl (Central amygdalar nucleus, lateral part) MBA:551 · Mouse

After CTB was injected iontophoretically into the lateral central amygdala, retrogradely labelled basal amygdala neurons were confined to the posterior subnucleus.

Fig. 6B

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AI (Agranular insular area) MBA:95 projects to LA (Lateral amygdalar nucleus) MBA:131 · Mouse

In medial amygdala sections, anterogradely labelled insular cortex axons innervated the posterior lateral amygdala subnucleus.

Fig. 3B; Supplementary Fig. S4

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BLAa (Basolateral amygdalar nucleus, anterior part) MBA:303 projects to HPF (Hippocampal formation) MBA:1089 · Mouse

Retrograde tracer injected into the ventral hippocampus/subiculum labelled basal amygdala neurons in both subnuclei, including the BAa.

Fig. 6C

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