Dopaminergic Modulation of Lateral Amygdala Neuronal Activity: Differential D1 and D2 Receptor Effects on Thalamic and Cortical Afferent Inputs

MG (Medial geniculate complex) UBERON:0001927 functionally connects to LA (lateral amygdaloid nucleus) UBERON:0002886 · Rat

Bipolar electrical stimulation of the medial geniculate nucleus in anesthetized rats evoked short-latency spikes (onset <20 ms, presumed monosynaptic) in putative lateral amygdala projection neurons recorded extracellularly; stimulus current was titrated so that roughly half of 50 trials produced an evoked spike.

Methods (Electrically Evoked Responses); Results, Figs. 3A1, 4A1

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

AUD (Auditory areas) UBERON:0001393 functionally connects to BLA (basal amygdaloid nucleus) UBERON:0002887 · Rat

Among the neurons driven by MGN or Te3 electrical stimulation, a few recording sites were verified inside the basolateral nucleus of the amygdala, showing that cortical auditory stimulation can evoke spiking in basolateral neurons as well as lateral nucleus neurons.

Results, Figs. 3B and 4B (distribution of recorded neurons)

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5-5) is unsure. “The text gives BLA cell counts pooled across MGN and Te3 stimulation, so whether any BLA cell was driven by Te3 rests on figures whose captions don't say.”

MG (Medial geniculate complex) UBERON:0001927 functionally connects to BLA (basal amygdaloid nucleus) UBERON:0002887 · Rat

A minority of the projection neurons that responded with evoked spikes to stimulation of the auditory thalamus or auditory association cortex were histologically localized to the basolateral nucleus rather than the lateral nucleus (4 cells in the D1 experiment, 7 in the D2 experiment), indicating these afferents also drive basolateral neurons.

Results, Figs. 3B and 4B (distribution of recorded neurons)

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5-5) is unsure. “The 4 and 7 BLA cells are pooled across both stimulation sites, so the text doesn't show that any of them responded to MGN rather than Te3.”

AUD (Auditory areas) UBERON:0001393 functionally connects to LA (lateral amygdaloid nucleus) UBERON:0002886 · Rat

Electrical stimulation of auditory association cortex (Te3) evoked short-latency spiking (<20 ms onset) in putative lateral amygdala projection neurons, although significantly larger stimulation currents were needed to reach the ~50% evoked-response baseline than for thalamic stimulation.

Methods (Electrically Evoked Responses); Results, Figs. 3A2, 3C, 4A2, 4C

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.