GABAergic Neurons in the Central Amygdala Promote Emergence from Isoflurane Anesthesia in Mice

CEA (Central amygdalar nucleus) MBA:536 projects to PALv (Pallidum, ventral region) MBA:835 · Mouse

Cre-dependent ChR2-mCherry was expressed in GABAergic (Vgat-Cre) neurons of the central amygdala, and labelled axonal fibres were visualized in the basal forebrain where the optic fibres were placed, showing that CeA GABAergic cells send terminals to the basal forebrain; optical stimulation of these terminals changed behaviour and cortical EEG.

Fig. 5A–C; Results, 'Activation of the GABAergic Central Amygdala–Basal Forebrain Circuit...'

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5-5) disagrees. “Fig. 5C does show ChR2-mCherry fibres in the basal forebrain, but the paper never establishes an inhibitory sign, so sign should be unknown; mapping the basal forebrain to ventral pallidum is also not specified by the paper.”