Basolateral amygdala projections to ventral hippocampus modulate the consolidation of footshock, but not contextual, learning in rats

BLA (basal amygdaloid nucleus) UBERON:0002887 projects to HPF (Hippocampal formation) UBERON:0002421 · Rat

After bilateral injection of AAV5-CaMKIIa-ChR2(E123A)-eYFP or AAV5-CaMKIIa-eArchT3.0-GFP into the basolateral amygdala, immunohistochemistry against the fluorescent tag revealed labelled cell bodies at the BLA injection site and labelled axons in the ventral hippocampus, where the optic fibers were placed just dorsal to the innervating fibers.

Fig. 5A,B; Materials and Methods (Surgery, Verification of opsin expression)

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BLA (basal amygdaloid nucleus) UBERON:0002887 functionally connects to CA1 (Field CA1) UBERON:0003881 · Rat

In anesthetized rats, 40-Hz blue-light pulses applied to ChR2-expressing BLA axons within the ventral hippocampus increased the firing of recorded ventral hippocampal CA1 neurons; when BLA cell bodies were stimulated with 473 nm light, simultaneous continuous 561 nm illumination of the BLA axons in VH (eArchT3.0) reduced this driven VH activity.

Fig. 5C,D; Methods, Electrophysiological verification

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5) agrees.