Claustrum mediates bidirectional and reversible control of stress-induced anxiety responses

ECT (Ectorhinal area) MBA:895 projects to CLA (Claustrum) MBA:583 · Mouse

Claustral retrograde tracing labelled projecting neurons in the ectorhinal area.

Fig. S6, B to K

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

BLAa (Basolateral amygdalar nucleus, anterior part) MBA:303 projects to CLA (Claustrum) MBA:583 · Mouse

After retrograde AAV injection into the claustrum, labelled BLA neurons appeared in the anterior BLA. Stress-tagged CLA-projecting BLA cells lay mainly in this anterior portion.

Fig. S7

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

ILA (Infralimbic area) MBA:44 projects to CLA (Claustrum) MBA:583 · Mouse

Retrograde tracing from the claustrum labelled CLA-projecting neurons in the prelimbic/infralimbic region of medial prefrontal cortex.

Fig. S6, B to K

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

BLA (Basolateral amygdalar nucleus) MBA:295 projects to CLA (Claustrum) MBA:583 · Mouse

Retrograde AAV injected into the anterior claustrum of TRAP2 mice labelled neurons in the basolateral amygdala. About 20% of the CLA-projecting BLA neurons were also tagged by social defeat stress, the highest share of any region examined.

Fig. S6, B to M

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

BLAp (Basolateral amygdalar nucleus, posterior part) MBA:311 projects to CLA (Claustrum) MBA:583 · Mouse

Retrogradely labelled (mCherry) CLA-projecting neurons were found in the posterior BLA as well as the anterior BLA. Stress-tagged cells, however, were concentrated anteriorly.

Fig. S7

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

AI (Agranular insular area) MBA:95 projects to CLA (Claustrum) MBA:583 · Mouse

Claustral retrograde AAV injection labelled neurons in the agranular insular cortex.

Fig. S6, B to K

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

PIR (Piriform area) MBA:961 projects to CLA (Claustrum) MBA:583 · Mouse

Claustral retrograde tracing labelled projecting neurons in piriform cortex.

Fig. S6, B to K

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

PL (Prelimbic area) MBA:972 projects to CLA (Claustrum) MBA:583 · Mouse

Retrograde tracing from the claustrum labelled CLA-projecting neurons in the prelimbic/infralimbic region of medial prefrontal cortex.

Fig. S6, B to K

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

ACA (Anterior cingulate area) MBA:31 projects to CLA (Claustrum) MBA:583 · Mouse

Retrograde AAV injected into the claustrum labelled neurons in the anterior cingulate area.

Fig. S6, B to K

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

ENT (Entorhinal area) MBA:909 projects to CLA (Claustrum) MBA:583 · Mouse

Claustral retrograde tracing labelled projecting neurons in entorhinal cortex.

Fig. S6, B to K

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

AON (Anterior olfactory nucleus) MBA:159 projects to CLA (Claustrum) MBA:583 · Mouse

Retrograde AAV injected into the claustrum labelled projecting neurons in the anterior olfactory area.

Fig. S6, B to K

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.