Forebrain Deletion of αGDI in Adult Mice Worsens the Pre-Synaptic Deficit at Cortico-Lateral Amygdala Synaptic Connections

MGm (Medial geniculate complex, medial part) MBA:1088 functionally connects to LA glutamatergic principal neurons nt-659aayyts5 · Mouse

Stimulation of the internal capsule, carrying thalamic (MGm) fibres, evoked monosynaptic excitatory postsynaptic currents in lateral amygdala principal neurons that scaled with stimulation intensity; maximal responses were normal in forebrain-restricted Gdi1 mutants but reduced in constitutive Gdi1-null mice.

Fig. 8D-F; Results, thalamo-LA input/output curves

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CTX (Cerebral cortex) MBA:688 functionally connects to LA glutamatergic principal neurons nt-659aayyts5 · Mouse

Placing a stimulating electrode in the external capsule of coronal amygdala slices evoked monosynaptic excitatory postsynaptic currents with stable latency and rise time in whole-cell recorded lateral amygdala principal neurons, recorded with GABA-A blockade (picrotoxin); current amplitude grew with stimulus strength and short-term plasticity could be probed with 20 Hz trains, with reduced maximal responses in Gdi1 mutants.

Fig. 6A-C, Fig. 7, Fig. 8A-C; Results, cortico-LA sections

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