Organization of Multisynaptic Inputs to the Dorsal and Ventral Dentate Gyrus: Retrograde Trans-Synaptic Tracing with Rabies Virus Vector in the Rat

ENTm (Entorhinal area, medial part, dorsal zone) UBERON:0018262 synapses onto DG (Dentate gyrus) UBERON:0001885 · Rat

First-order rabies labeling at three days was found in the medial entorhinal cortex, laterally and caudally for dorsal DG injections and medially for ventral DG injections.

Fig. 2, Fig. 3, Fig. 7A,D

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

PRE (Presubiculum) UBERON:0001953 synapses onto DG (Dentate gyrus) UBERON:0001885 · Rat

After dorsal DG injections, presubiculum labeling was absent at three days but dense in some five-day cases, consistent with an indirect rather than monosynaptic input.

Fig. 2F, Fig. 4F

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

LS (Lateral septal nucleus) UBERON:0002667 synapses onto DG (Dentate gyrus) UBERON:0001885 · Rat

Lateral septum labeling was missing at three days and present at five days, so it is interpreted as a disynaptic input to the DG.

Results, Single-virus injection; Fig. 2-5

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

CS (Superior central nucleus raphe) UBERON:0003004 synapses onto DG (Dentate gyrus) UBERON:0001885 · Rat

A small number of median raphe neurons were labeled three days after rabies injection, in three of four dorsal DG cases and all three ventral DG cases.

Fig. 2F, Fig. 3F

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

SUM (Supramammillary nucleus) UBERON:0001940 synapses onto DG (Dentate gyrus) UBERON:0001885 · Rat

Supramammillary neurons were labeled at three days after DG rabies injection; ventral-DG-innervating cells lay more medially than dorsal-DG-innervating cells.

Fig. 2, Fig. 3, Fig. 7B,E

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

ENTl (Entorhinal area, lateral part) UBERON:0007225 synapses onto DG (Dentate gyrus) UBERON:0001885 · Rat

Three days after rabies vector injection into dorsal or ventral dentate gyrus, first-order labeled neurons appeared in the lateral entorhinal cortex, lateral parts for dorsal DG and medial parts for ventral DG.

Fig. 2, Fig. 3, Fig. 7A,D

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

IPN (Interpeduncular nucleus) UBERON:0002145 synapses onto DG (Dentate gyrus) UBERON:0001885 · Rat

At three days, a few interpeduncular neurons were labeled in three of four dorsal DG cases and one of three ventral DG cases.

Results, Single-virus injection

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

EP (Endopiriform nucleus) UBERON:0014284 synapses onto DG (Dentate gyrus) UBERON:0001885 · Rat

Endopiriform neurons were not labeled at the three-day monosynaptic time point, only after five days, indicating indirect rather than direct input to the DG.

Results, Single-virus injection; Fig. 2-5

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

NDB (Diagonal band nucleus) UBERON:0001879 synapses onto DG (Dentate gyrus) UBERON:0001885 · Rat

Diagonal band neurons were labeled as first-order inputs three days after rabies injection into dorsal or ventral DG.

Fig. 2, Fig. 3, Fig. 7C,F

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

MH (Medial habenula) UBERON:0001942 synapses onto DG (Dentate gyrus) UBERON:0001885 · Rat

Medial habenula neurons were labeled only after five days of survival and not at three days, indicating they are second-order rather than direct DG inputs.

Results, Single-virus injection; Fig. 2-5

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

MS (Medial septal nucleus) UBERON:0001877 synapses onto DG (Dentate gyrus) UBERON:0001885 · Rat

Many medial septum neurons were labeled three days after DG rabies injection, with dorsal-DG-projecting cells located more medially than ventral-DG-projecting cells.

Fig. 2, Fig. 3, Fig. 7C,F

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

ILA (Infralimbic area) UBERON:8440033 synapses onto DG (Dentate gyrus) UBERON:0001885 · Rat

Infralimbic labeling was absent at the three-day survival and appeared only at five days, so it is considered a second-order input to the DG.

Results, Single-virus injection; Fig. 9

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

PL (Prelimbic area) UBERON:8440032 synapses onto DG (Dentate gyrus) UBERON:0001885 · Rat

Medial prefrontal (prelimbic) labeling was absent at three days and appeared only at five days, implying an indirect route to the DG.

Results, Single-virus injection; Fig. 9

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

CLA (Claustrum) UBERON:0002023 synapses onto DG (Dentate gyrus) UBERON:0001885 · Rat

A few claustral neurons were labeled three days after rabies injection in three of four dorsal DG cases and one of three ventral DG cases.

Results, Single-virus injection

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

Pir (piriform cortex) UBERON:0004725 synapses onto DG (Dentate gyrus) UBERON:0001885 · Rat

Piriform labeling was absent at three days and appeared only at five days, so the authors treat the piriform cortex as a second-order rather than direct input to the DG.

Results, Single-virus injection; Fig. 2-5

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.