Whole-Brain Mapping of Inputs to Projection Neurons and Cholinergic Interneurons in the Dorsal Striatum

SSp (Primary somatosensory area) MBA:322 synapses onto STRd (Striatum dorsal region) MBA:485 · Mouse

Somatosensory cortex contained rabies-labelled presynaptic cells of striatal cholinergic interneurons.

Fig 4B; Fig 3

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

TH (Thalamus) MBA:549 synapses onto STRd (Striatum dorsal region) MBA:485 · Mouse

The thalamus supplied about a tenth of rabies-labelled inputs to striatal cholinergic interneurons.

Fig 4A

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

GPe (Globus pallidus, external segment) MBA:1022 synapses onto STRd (Striatum dorsal region) MBA:485 · Mouse

Cholinergic interneurons received rabies-labelled inputs from the external globus pallidus.

Fig 4B; Fig 5D

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

PF (Parafascicular nucleus) MBA:930 synapses onto STRd (Striatum dorsal region) MBA:485 · Mouse

Parafascicular thalamus contained heavy rabies labelling of inputs to D2 MSNs.

Fig 4B; Fig 7

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

VAL (Ventral anterior-lateral complex of the thalamus) MBA:629 synapses onto STRd (Striatum dorsal region) MBA:485 · Mouse

Ventrolateral thalamus contained rabies-labelled inputs to cholinergic interneurons.

Fig 3

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) is unsure. “VL appears only in the Fig 3 abbreviation list; the text never describes VL labelling for cholinergic starters.”

BLA (Basolateral amygdalar nucleus) MBA:295 synapses onto STRd (Striatum dorsal region) MBA:485 · Mouse

The basolateral amygdala held substantial rabies-labelled inputs to striatal cholinergic interneurons.

Fig 4B; Fig 3

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

STRd (Striatum dorsal region) MBA:485 projects to GPi (Globus pallidus, internal segment) MBA:1031 · Mouse

A Cre-dependent membrane GFP vector injected into the dorsal striatum of D1-Cre mice labelled terminals in the internal globus pallidus/entopeduncular nucleus.

Fig 1B

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

DR (Dorsal nucleus raphe) MBA:872 synapses onto STRd (Striatum dorsal region) MBA:485 · Mouse

Only a few dorsal raphe neurons were rabies-labelled as inputs to cholinergic interneurons.

Fig 5F; Fig 3B

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

BLA (Basolateral amygdalar nucleus) MBA:295 synapses onto STRd (Striatum dorsal region) MBA:485 · Mouse

The basolateral amygdala contained substantial rabies labelling of inputs to D2 MSNs.

Fig 4B; Fig 3A

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

ACA (Anterior cingulate area) MBA:31 synapses onto STRd (Striatum dorsal region) MBA:485 · Mouse

Starting from D1 MSNs, rabies labelled dense presynaptic neurons in the cingulate cortex; wild-type controls showed none.

Fig 2C, 2E; Fig 5A

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

STRd (Striatum dorsal region) MBA:485 projects to SNr (Substantia nigra, reticular part) MBA:381 · Mouse

In D1-Cre mice, axon terminals from Cre-dependent EmGFP-labelled striatal cells were seen in the substantia nigra pars reticulata.

Fig 1B

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

RSP (Retrosplenial area) MBA:254 synapses onto STRd (Striatum dorsal region) MBA:485 · Mouse

Sagittal sections from a ChAT-Cre mouse showed rabies-labelled input neurons in retrosplenial cortex.

Fig 3B

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) is unsure. “Retrosplenial cortex appears only as an abbreviation in the Fig 3 caption, with no labelling result described.”

MD (Mediodorsal nucleus of thalamus) MBA:362 synapses onto STRd (Striatum dorsal region) MBA:485 · Mouse

The mediodorsal thalamus was one of the areas where inputs to D2 MSNs clustered.

Fig 7

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

MO (Somatomotor areas) MBA:500 synapses onto STRd (Striatum dorsal region) MBA:485 · Mouse

Rabies tracing from cholinergic interneurons labelled input neurons in motor cortex, including M2.

Fig 4B; Fig 5A

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

VIS (Visual areas) MBA:669 synapses onto STRd (Striatum dorsal region) MBA:485 · Mouse

Cholinergic interneurons had rabies-labelled inputs in visual cortex, including V2.

Fig 4B; Fig 5B

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

STN (Subthalamic nucleus) MBA:470 synapses onto STRd (Striatum dorsal region) MBA:485 · Mouse

The subthalamic nucleus contained rabies-labelled inputs to D2 MSNs.

Fig 3A; Fig 7

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) is unsure. “The subthalamic nucleus appears only in figure abbreviation lists; the text gives no labelling result for it.”

AUD (Auditory areas) MBA:247 synapses onto STRd (Striatum dorsal region) MBA:485 · Mouse

Labelling of D2 MSN inputs in auditory cortex was sparse.

Fig 4B

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

ORB (Orbital area) MBA:714 synapses onto STRd (Striatum dorsal region) MBA:485 · Mouse

Orbital cortex (LO/VO) contained rabies-labelled input neurons to cholinergic interneurons.

Fig 3B

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) is unsure. “LO/VO appear only as abbreviations in the Fig 3 caption, with no described result for cholinergic starters.”

AUD (Auditory areas) MBA:247 synapses onto STRd (Striatum dorsal region) MBA:485 · Mouse

Auditory cortex contained only light rabies labelling of inputs to cholinergic interneurons.

Fig 4B; Fig 3B

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

CTX (Cerebral cortex) MBA:688 synapses onto STRd (Striatum dorsal region) MBA:485 · Mouse

About a third of rabies-labelled inputs to striatal cholinergic interneurons were in the cortex, a smaller share than for MSNs.

Fig 4A

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

LP (Lateral posterior nucleus of the thalamus) MBA:218 synapses onto STRd (Striatum dorsal region) MBA:485 · Mouse

Rabies-labelled inputs to cholinergic interneurons appeared in the lateral posterior thalamus.

Fig 3

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) is unsure. “LPMR appears only in the Fig 3 abbreviation list; no labelling result is described for it.”

SNc (Substantia nigra, compact part) MBA:374 synapses onto STRd (Striatum dorsal region) MBA:485 · Mouse

SNc showed heavy rabies labelling of inputs to striatal cholinergic interneurons.

Fig 4B; Fig 5E

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

DR (Dorsal nucleus raphe) MBA:872 synapses onto STRd (Striatum dorsal region) MBA:485 · Mouse

Rabies tracing from D2 MSNs labelled only a few neurons in the dorsal raphe.

Fig 5F

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

ILM (Intralaminar nuclei of the dorsal thalamus) MBA:51 synapses onto STRd (Striatum dorsal region) MBA:485 · Mouse

CL/PC thalamus contained heavy rabies labelling of inputs to cholinergic interneurons.

Fig 4B; Fig 5C

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

STRd (Striatum dorsal region) MBA:485 projects to GPe (Globus pallidus, external segment) MBA:1022 · Mouse

Cre-dependent EmGFP in the dorsal striatum of D2-Cre mice labelled extrastriatal terminals mainly in the external globus pallidus.

Fig 1C

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

ACA (Anterior cingulate area) MBA:31 synapses onto STRd (Striatum dorsal region) MBA:485 · Mouse

Cingulate cortex contained rabies-labelled presynaptic cells of striatal cholinergic interneurons.

Fig 4B; Fig 5A

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

STN (Subthalamic nucleus) MBA:470 synapses onto STRd (Striatum dorsal region) MBA:485 · Mouse

Subthalamic neurons were among the rabies-labelled inputs to cholinergic interneurons.

Fig 3; Fig 7

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) is unsure. “The subthalamic nucleus appears only in figure abbreviation lists; the text describes no result for it.”

PIR (Piriform area) MBA:961 synapses onto STRd (Striatum dorsal region) MBA:485 · Mouse

Piriform cortex held few rabies-labelled inputs to cholinergic interneurons.

Fig 4B

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

PF (Parafascicular nucleus) MBA:930 synapses onto STRd (Striatum dorsal region) MBA:485 · Mouse

Parafascicular thalamus showed heavy rabies labelling of inputs to cholinergic interneurons.

Fig 4B; Fig 3B

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

SSp (Primary somatosensory area) MBA:322 synapses onto STRd (Striatum dorsal region) MBA:485 · Mouse

Many rabies-labelled cortical inputs to D2 MSNs were in the ipsilateral somatosensory cortex.

Fig 4B; Fig 3A

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

PTLp (Posterior parietal association areas) MBA:22 synapses onto STRd (Striatum dorsal region) MBA:485 · Mouse

Rabies-labelled inputs to cholinergic interneurons were seen in parietal association cortex.

Fig 3B

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) is unsure. “PtA appears only as an abbreviation in the Fig 3 caption, with no labelling result described.”