Cortico-cortical connectivity behind acoustic information transfer to mouse orbitofrontal cortex is sensitive to neuromodulation and displays local sensory gating: relevance in disorders with auditory hallucinations?

AUDp (Primary auditory area) MBA:1002 projects to ORB (Orbital area) MBA:714 · Mouse

Only a small share of OFC-projecting neurons labelled by Fluoro-Gold in ventral orbital OFC lay in the primary auditory cortex. This was about 1.85% of labelled cortical cells outside the OFC.

Results, Direct anatomic connection between mouse AAC and OFC; Fig. 2C-D

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

TEa (Temporal association areas) MBA:541 projects to ORB (Orbital area) MBA:714 · Mouse

Ventral orbital OFC Fluoro-Gold injections labelled many neurons in the temporal association area, the largest auditory-related source. It held about 12.5% of labelled cortical cells outside the OFC.

Results, Direct anatomic connection between mouse AAC and OFC; Fig. 2B′-D

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

AUDv (Ventral auditory area) MBA:1018 projects to ORB (Orbital area) MBA:714 · Mouse

Fluoro-Gold injected iontophoretically into the ventral orbital OFC retrogradely labelled ipsilateral neurons in the ventral secondary auditory cortex in every animal. These made up about 4.4% of cortical labelled cells outside the OFC.

Results, Direct anatomic connection between mouse AAC and OFC; Fig. 2C-D

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

AUDd (Dorsal auditory area) MBA:1011 projects to ORB (Orbital area) MBA:714 · Mouse

After Fluoro-Gold injection into ventral orbital OFC, retrogradely labelled neurons were found in the dorsal secondary auditory cortex. They accounted for about 5.25% of labelled cortical cells outside the OFC.

Results, Direct anatomic connection between mouse AAC and OFC; Fig. 2C-D

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.