Dopamine D2 Receptors in the Paraventricular Thalamus Attenuate Cocaine Locomotor Sensitization

ORB (Orbital area) MBA:714 synapses onto PVT (Paraventricular nucleus of the thalamus) MBA:149 · Mouse

Neurons in orbital frontal cortex were labelled by monosynaptic rabies tracing started from PVT D2R-expressing neurons.

Results, PVT afferents; Fig. 5; Table 1

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

PVT (Paraventricular nucleus of the thalamus) MBA:149 projects to PL (Prelimbic area) MBA:972 · Mouse

Cre-dependent AAV5-DIO-eYFP injected into the PVT of Drd2-Cre mice produced heavily labelled axons in prelimbic cortex.

Fig. 3A,B; Table 1

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

PVT (Paraventricular nucleus of the thalamus) MBA:149 projects to ACB (Nucleus accumbens) MBA:56 · Mouse

With a Cre-off AAV1-hsyn-FAS-GCaMP6f labelling D2R-negative PVT cells, their axons reached the nucleus accumbens and were concentrated in the core, overlapping partly with D2R-positive projections.

Fig. 4C,D

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

ARH (Arcuate hypothalamic nucleus) MBA:223 synapses onto PVT (Paraventricular nucleus of the thalamus) MBA:149 · Mouse

Rabies tracing from PVT D2R neurons labelled neurons in the arcuate hypothalamic nucleus.

Results, PVT afferents; Table 1

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

PVT (Paraventricular nucleus of the thalamus) MBA:149 projects to AI (Agranular insular area) MBA:95 · Mouse

eYFP-labelled fibres from Cre-dependent anterograde tracing of PVT D2R neurons were abundant in agranular insular cortex.

Fig. 3A,C; Table 1

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

ACB (Nucleus accumbens) MBA:56 synapses onto PVT (Paraventricular nucleus of the thalamus) MBA:149 · Mouse

Pseudotyped rabies tracing from PVT D2R neurons labelled cell bodies in the nucleus accumbens, shown for the core.

Fig. 5D; Table 1

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

ACA (Anterior cingulate area) MBA:31 synapses onto PVT (Paraventricular nucleus of the thalamus) MBA:149 · Mouse

Monosynaptic rabies tracing from PVT D2R neurons revealed non-reciprocal input from cingulate cortex.

Results, PVT afferents; Table 1

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

VMH (Ventromedial hypothalamic nucleus) MBA:693 synapses onto PVT (Paraventricular nucleus of the thalamus) MBA:149 · Mouse

Monosynaptic rabies tracing from PVT D2R neurons labelled neurons in the ventromedial hypothalamus.

Results, PVT afferents; Table 1

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

PVT (Paraventricular nucleus of the thalamus) MBA:149 projects to BLA (Basolateral amygdalar nucleus) MBA:295 · Mouse

Anterograde tracing from PVT D2R neurons labelled fibres in the basal (basolateral) amygdala.

Fig. 3A,F; Table 1

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

PVT (Paraventricular nucleus of the thalamus) MBA:149 projects to BST (Bed nuclei of the stria terminalis) MBA:351 · Mouse

Cre-dependent anterograde tracer in PVT D2R neurons labelled dense fibres in the BNST.

Fig. 3A,E; Table 1

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

SCH (Suprachiasmatic nucleus) MBA:286 synapses onto PVT (Paraventricular nucleus of the thalamus) MBA:149 · Mouse

Monosynaptic rabies tracing from PVT D2R-expressing neurons labelled cells in the suprachiasmatic nucleus.

Results, PVT afferents; Table 1

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

VTA (Ventral tegmental area) MBA:749 synapses onto PVT (Paraventricular nucleus of the thalamus) MBA:149 · Mouse

Monosynaptic rabies tracing from PVT D2R-expressing neurons labelled cell bodies in the VTA.

Results, PVT afferents; Table 1

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

PVT (Paraventricular nucleus of the thalamus) MBA:149 projects to CP (Caudoputamen) MBA:672 · Mouse

Only sparse eYFP-labelled axons from PVT D2R neurons were seen in the caudate putamen.

Results, PVT efferents; Table 1

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

PVT (Paraventricular nucleus of the thalamus) MBA:149 projects to CEA (Central amygdalar nucleus) MBA:536 · Mouse

eYFP fibres from PVT D2R-expressing neurons were present in the central amygdala.

Fig. 3A,F; Table 1

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

CP (Caudoputamen) MBA:672 synapses onto PVT (Paraventricular nucleus of the thalamus) MBA:149 · Mouse

Retrogradely labelled neurons after monosynaptic rabies tracing from PVT D2R cells were found in the caudate putamen.

Results, PVT afferents; Table 1

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

AI (Agranular insular area) MBA:95 synapses onto PVT (Paraventricular nucleus of the thalamus) MBA:149 · Mouse

Monosynaptic pseudotyped rabies tracing from PVT D2R-expressing neurons retrogradely labelled cell bodies in agranular insular cortex.

Fig. 5A,C; Table 1

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

AHN (Anterior hypothalamic nucleus) MBA:88 synapses onto PVT (Paraventricular nucleus of the thalamus) MBA:149 · Mouse

Input neurons to PVT D2R cells were retrogradely labelled in the anterior hypothalamus.

Results, PVT afferents; Table 1

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

PVT (Paraventricular nucleus of the thalamus) MBA:149 projects to ENT (Entorhinal area) MBA:909 · Mouse

Sparse labelling of axons from PVT D2R-expressing neurons was observed in entorhinal cortex.

Results, PVT efferents; Table 1

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

PH (Posterior hypothalamic nucleus) MBA:946 synapses onto PVT (Paraventricular nucleus of the thalamus) MBA:149 · Mouse

Monosynaptic rabies labelling from PVT D2R neurons included cells in the posterior hypothalamus.

Results, PVT afferents; Table 1

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

BST (Bed nuclei of the stria terminalis) MBA:351 synapses onto PVT (Paraventricular nucleus of the thalamus) MBA:149 · Mouse

Monosynaptic rabies tracing from PVT D2R neurons labelled neurons in the bed nucleus of the stria terminalis.

Fig. 5F; Table 1

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

LHA (Lateral hypothalamic area) MBA:194 synapses onto PVT (Paraventricular nucleus of the thalamus) MBA:149 · Mouse

Rabies tracing from PVT D2R neurons labelled neurons in the lateral hypothalamic area.

Results, PVT afferents; Table 1

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

PVT (Paraventricular nucleus of the thalamus) MBA:149 projects to ACB (Nucleus accumbens) MBA:56 · Mouse

Anterograde labelling of PVT D2R-expressing neurons gave patchy terminal fields in the nucleus accumbens, densest in the medial shell.

Fig. 3A,D; Table 1

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

RT (Reticular nucleus of the thalamus) MBA:262 synapses onto PVT (Paraventricular nucleus of the thalamus) MBA:149 · Mouse

Rabies tracing from PVT D2R neurons labelled cells in the reticular nucleus of the thalamus.

Results, PVT afferents; Table 1

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

PB (Parabrachial nucleus) MBA:867 synapses onto PVT (Paraventricular nucleus of the thalamus) MBA:149 · Mouse

Monosynaptic rabies tracing from PVT D2R neurons labelled cells in the lateral parabrachial nucleus.

Results, PVT afferents; Table 1

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

SUM (Supramammillary nucleus) MBA:525 synapses onto PVT (Paraventricular nucleus of the thalamus) MBA:149 · Mouse

Input cells to PVT D2R neurons were labelled in the supramammillary nucleus.

Results, PVT afferents; Table 1

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

ZI (Zona incerta) MBA:797 synapses onto PVT (Paraventricular nucleus of the thalamus) MBA:149 · Mouse

Neurons in the zona incerta were retrogradely labelled by monosynaptic rabies tracing from PVT D2R-expressing cells.

Fig. 5H; Table 1

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

DMH (Dorsomedial nucleus of the hypothalamus) MBA:830 synapses onto PVT (Paraventricular nucleus of the thalamus) MBA:149 · Mouse

Retrogradely labelled input neurons were found in the dorsomedial hypothalamus after rabies tracing from PVT D2R cells.

Results, PVT afferents; Table 1

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

LC (Locus ceruleus) MBA:147 synapses onto PVT (Paraventricular nucleus of the thalamus) MBA:149 · Mouse

Rabies tracing from PVT D2R neurons retrogradely labelled neurons in the locus coeruleus.

Results, PVT afferents; Table 1

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

LS (Lateral septal nucleus) MBA:242 synapses onto PVT (Paraventricular nucleus of the thalamus) MBA:149 · Mouse

Rabies tracing from PVT D2R-expressing neurons labelled cell bodies in the lateral septum.

Fig. 5E; Table 1

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

LA (Lateral amygdalar nucleus) MBA:131 synapses onto PVT (Paraventricular nucleus of the thalamus) MBA:149 · Mouse

Retrograde rabies labelling from PVT D2R neurons revealed input neurons in the lateral amygdala.

Results, PVT afferents; Table 1

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

CEA (Central amygdalar nucleus) MBA:536 synapses onto PVT (Paraventricular nucleus of the thalamus) MBA:149 · Mouse

Cells in the central amygdala were retrogradely labelled by pseudotyped rabies virus started from PVT D2R-expressing neurons.

Fig. 5G; Table 1

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

PL (Prelimbic area) MBA:972 synapses onto PVT (Paraventricular nucleus of the thalamus) MBA:149 · Mouse

Rabies-based monosynaptic retrograde tracing from PVT D2R neurons labelled neurons in prelimbic cortex.

Fig. 5A,B; Table 1

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

BLA (Basolateral amygdalar nucleus) MBA:295 synapses onto PVT (Paraventricular nucleus of the thalamus) MBA:149 · Mouse

Monosynaptic rabies tracing from PVT D2R neurons labelled neurons in the basal amygdala, a non-reciprocal input.

Results, PVT afferents; Table 1

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

RAmb (Midbrain raphe nuclei) MBA:165 synapses onto PVT (Paraventricular nucleus of the thalamus) MBA:149 · Mouse

Rabies tracing from PVT D2R-expressing neurons labelled neurons in the raphe nuclei.

Results, PVT afferents; Table 1

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

PVT (Paraventricular nucleus of the thalamus) MBA:149 projects to LA (Lateral amygdalar nucleus) MBA:131 · Mouse

eYFP-labelled axons from PVT D2R-expressing neurons were found in the lateral nucleus of the amygdala.

Fig. 3A,F; Table 1

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

VTA (Ventral tegmental area) MBA:749 synapses onto PVT (Paraventricular nucleus of the thalamus) MBA:149 · Mouse

Although rabies-labelled input cells were present in the VTA, none of them were immunoreactive for tyrosine hydroxylase, so no catecholaminergic VTA input to PVT D2R neurons was detected.

Results, after Fig. 5 (data not shown)

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

PAG (Periaqueductal gray) MBA:795 synapses onto PVT (Paraventricular nucleus of the thalamus) MBA:149 · Mouse

Rabies tracing from PVT D2R neurons labelled neurons in the periaqueductal gray.

Results, PVT afferents; Table 1

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.