Anatomical Connectivity of the Intercalated Cells of the Amygdala

PoT (Posterior triangular thalamic nucleus) MBA:563807435 synapses onto Intercalated cell GABAergic neurons nt-y231zwbxhf · Mouse

The posterior triangular thalamic nucleus held dense groups of presynaptic neurons to lateral ITCs.

Fig. 7c-d; Results, Lateral ITCs

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AUDv (Ventral auditory area) MBA:1018 synapses onto Intercalated cell GABAergic neurons nt-y231zwbxhf · Mouse

Ventral auditory cortex contained rabies-labelled inputs to main ITCs.

Fig. 3c-d; Results, Main ITC nucleus

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Intercalated cell GABAergic neurons nt-y231zwbxhf projects to CEA (Central amygdalar nucleus) MBA:536 · Mouse

Unlike main ITCs, caudal ITCs sent only a few axons into the central amygdala.

Fig. 4; Results, Caudal ITCs

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Intercalated cell GABAergic neurons nt-y231zwbxhf projects to NDB (Diagonal band nucleus) MBA:596 · Mouse

Main ITC terminals were dense in the horizontal limb of the diagonal band of the basal forebrain.

Fig. 2b-c; Results, Main ITC nucleus

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PP (Peripeduncular nucleus) MBA:1044 synapses onto Intercalated cell GABAergic neurons nt-y231zwbxhf · Mouse

The peripeduncular nucleus contained rabies-labelled inputs to caudal ITCs.

Fig. 5c-d; Results, Caudal ITCs

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Intercalated cell GABAergic neurons nt-y231zwbxhf projects to IA (Intercalated amygdalar nucleus) MBA:1105 · Mouse

Caudal ITCs projected densely to other ITC clusters, the main ITC nucleus being among the densest targets.

Fig. 4b-c; Results, Caudal ITCs

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ENTl (Entorhinal area, lateral part) MBA:918 synapses onto Intercalated cell GABAergic neurons nt-y231zwbxhf · Mouse

Dorsolateral entorhinal cortex provided presynaptic input to caudal ITCs.

Fig. 5c-d; Results, Caudal ITCs

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IMD (Intermediodorsal nucleus of the thalamus) MBA:59 synapses onto Intercalated cell GABAergic neurons nt-y231zwbxhf · Mouse

Lateral ITCs stood apart by receiving notable input from the intermediodorsal thalamic nucleus.

Fig. 7c-d; Results, Lateral ITCs

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Intercalated cell GABAergic neurons nt-y231zwbxhf projects to BMA (Basomedial amygdalar nucleus) MBA:319 · Mouse

Caudal ITC fluorescence in the basomedial amygdala was present but comparatively light.

Fig. 4; Results, Caudal ITCs

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CA1sp (Field CA1, pyramidal layer) MBA:407 synapses onto Intercalated cell GABAergic neurons nt-y231zwbxhf · Mouse

Dense rabies-labelled presynaptic cells were found in the CA1 pyramidal layer after main ITC starter infection.

Fig. 3c-d; Results, Main ITC nucleus

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AI (Agranular insular area) MBA:95 synapses onto Intercalated cell GABAergic neurons nt-y231zwbxhf · Mouse

Monosynaptic rabies tracing from caudal ITCs labelled clusters of presynaptic cells in the insular cortex.

Fig. 5c-d; Results, Caudal ITCs

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SI (Substantia innominata) MBA:342 synapses onto Intercalated cell GABAergic neurons nt-y231zwbxhf · Mouse

The substantia innominata contained many scattered rabies-labelled inputs to main ITCs.

Fig. 3c-d; Results, Main ITC nucleus

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Intercalated cell GABAergic neurons nt-y231zwbxhf projects to BST (Bed nuclei of the stria terminalis) MBA:351 · Mouse

Main ITC axons reached the BNST by travelling caudally through the caudal ITCs and the stria terminalis, entering it from its dorsal side.

Fig. 2b-c; Results, Main ITC nucleus

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CEA (Central amygdalar nucleus) MBA:536 synapses onto Intercalated cell GABAergic neurons nt-y231zwbxhf · Mouse

Rabies tracing from main ITCs labelled presynaptic cells in the central amygdala.

Fig. 3c-d; Results, Main ITC nucleus

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MEA (Medial amygdalar nucleus) MBA:403 synapses onto Intercalated cell GABAergic neurons nt-y231zwbxhf · Mouse

Caudal ITCs received input from the same amygdala regions as main ITCs, the medial amygdala among them, in similar proportions.

Fig. 5; Results, Caudal ITCs

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PF (Parafascicular nucleus) MBA:930 synapses onto Intercalated cell GABAergic neurons nt-y231zwbxhf · Mouse

The parafascicular thalamic nucleus provided rabies-labelled input to caudal ITCs.

Fig. 5c-d; Results, Caudal ITCs

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Intercalated cell GABAergic neurons nt-y231zwbxhf projects to COA (Cortical amygdalar area) MBA:631 · Mouse

Main ITC synaptic outputs were found in most parts of the cortical amygdala.

Fig. 2b-c; Results, Main ITC nucleus

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Intercalated cell GABAergic neurons nt-y231zwbxhf projects to MEA (Medial amygdalar nucleus) MBA:403 · Mouse

Cre-dependent synaptophysin-eGFP tracing from FoxP2+ main ITCs labelled dense terminals across the whole rostrocaudal extent of the medial amygdala.

Fig. 2b-c; Results, Main ITC nucleus

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ENT (Entorhinal area) MBA:909 synapses onto Intercalated cell GABAergic neurons nt-y231zwbxhf · Mouse

Entorhinal cortex neurons were consistently labelled as presynaptic to main ITCs.

Fig. 3c-d; Results, Main ITC nucleus

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Intercalated cell GABAergic neurons nt-y231zwbxhf projects to BMA (Basomedial amygdalar nucleus) MBA:319 · Mouse

Anterograde synaptophysin labelling from main ITCs reached much of the basomedial amygdala.

Fig. 2b-c; Results, Main ITC nucleus

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AAA (Anterior amygdalar area) MBA:23 synapses onto Intercalated cell GABAergic neurons nt-y231zwbxhf · Mouse

Caudal ITCs received input from the anterior amygdaloid area, one of the amygdalar sources they share with main ITCs.

Fig. 5; Results, Caudal ITCs

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BLA (Basolateral amygdalar nucleus) MBA:295 synapses onto Intercalated cell GABAergic neurons nt-y231zwbxhf · Mouse

Only a few basolateral amygdala neurons were labelled as presynaptic to lateral ITCs.

Fig. 7; Results, Lateral ITCs

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MA (Magnocellular nucleus) MBA:298 synapses onto Intercalated cell GABAergic neurons nt-y231zwbxhf · Mouse

Rabies-labelled presynaptic neurons to main ITCs were seen in the magnocellular preoptic nucleus.

Fig. 3c-d; Results, Main ITC nucleus

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Intercalated cell GABAergic neurons nt-y231zwbxhf projects to SI (Substantia innominata) MBA:342 · Mouse

The substantia innominata received dense synaptophysin-labelled input from main ITCs.

Fig. 2b-c; Results, Main ITC nucleus

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PIL (Posterior intralaminar thalamic nucleus) MBA:560581563 synapses onto Intercalated cell GABAergic neurons nt-y231zwbxhf · Mouse

Posterior intralaminar thalamic neurons were presynaptic to caudal ITCs.

Fig. 5c-d; Results, Caudal ITCs

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Intercalated cell GABAergic neurons nt-y231zwbxhf projects to COA (Cortical amygdalar area) MBA:631 · Mouse

Caudal ITCs gave light projections to the cortical amygdala.

Fig. 4; Results, Caudal ITCs

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PSTN (Parasubthalamic nucleus) MBA:364 synapses onto Intercalated cell GABAergic neurons nt-y231zwbxhf · Mouse

The parasubthalamic nucleus contained presynaptic neurons to caudal ITCs.

Fig. 5c-d; Results, Caudal ITCs

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Intercalated cell GABAergic neurons nt-y231zwbxhf projects to MEA (Medial amygdalar nucleus) MBA:403 · Mouse

Caudal ITC synaptophysin labelling was densest in the medial amygdala, especially its anterior and caudal dorsal parts.

Fig. 4b-c; Results, Caudal ITCs

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PVT (Paraventricular nucleus of the thalamus) MBA:149 synapses onto Intercalated cell GABAergic neurons nt-y231zwbxhf · Mouse

Dense clusters of presynaptic neurons to caudal ITCs were found in the anterior paraventricular thalamus.

Fig. 5c-d; Results, Caudal ITCs

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PVT (Paraventricular nucleus of the thalamus) MBA:149 synapses onto Intercalated cell GABAergic neurons nt-y231zwbxhf · Mouse

Lateral ITCs received anterior paraventricular thalamic input, though much less than the main and caudal ITCs.

Fig. 7; Results, Lateral ITCs

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ILA (Infralimbic area) MBA:44 synapses onto Intercalated cell GABAergic neurons nt-y231zwbxhf · Mouse

No rabies-labelled presynaptic neurons were found in infralimbic cortex after tracing from main ITCs.

Results, Main ITC nucleus

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MD (Mediodorsal nucleus of thalamus) MBA:362 synapses onto Intercalated cell GABAergic neurons nt-y231zwbxhf · Mouse

Presynaptic neurons to lateral ITCs were labelled in the medial part of the mediodorsal thalamus.

Fig. 7c-d; Results, Lateral ITCs

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Intercalated cell GABAergic neurons nt-y231zwbxhf projects to NLOT (Nucleus of the lateral olfactory tract) MBA:619 · Mouse

As with main ITCs, caudal ITC terminals completely avoided the nucleus of the lateral olfactory tract.

Results, Caudal ITCs

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TEa (Temporal association areas) MBA:541 synapses onto Intercalated cell GABAergic neurons nt-y231zwbxhf · Mouse

Temporal association cortex neurons were labelled as presynaptic to main ITCs.

Fig. 3c-d; Results, Main ITC nucleus

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PO (Posterior complex of the thalamus) MBA:1020 synapses onto Intercalated cell GABAergic neurons nt-y231zwbxhf · Mouse

The posterior thalamic nuclei were among the densest sources of rabies-labelled input to main ITCs.

Fig. 3c-d; Results, Main ITC nucleus

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COApl (Cortical amygdalar area, posterior part, lateral zone) MBA:655 synapses onto Intercalated cell GABAergic neurons nt-y231zwbxhf · Mouse

The posterolateral cortical amygdala contained rabies-labelled inputs to main ITCs.

Fig. 3c-d; Results, Main ITC nucleus

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PERI (Perirhinal area) MBA:922 synapses onto Intercalated cell GABAergic neurons nt-y231zwbxhf · Mouse

Perirhinal cortex contained clusters of rabies-labelled inputs to caudal ITCs.

Fig. 5c-d; Results, Caudal ITCs

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COApm (Cortical amygdalar area, posterior part, medial zone) MBA:663 synapses onto Intercalated cell GABAergic neurons nt-y231zwbxhf · Mouse

Presynaptic cells were found in the posteromedial cortical amygdala after rabies tracing from main ITCs.

Fig. 3c-d; Results, Main ITC nucleus

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PVT (Paraventricular nucleus of the thalamus) MBA:149 synapses onto Intercalated cell GABAergic neurons nt-y231zwbxhf · Mouse

The paraventricular thalamus provided some of the densest presynaptic labelling onto main ITCs.

Fig. 3c-d; Results, Main ITC nucleus

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NDB (Diagonal band nucleus) MBA:596 synapses onto Intercalated cell GABAergic neurons nt-y231zwbxhf · Mouse

Presynaptic neurons to main ITCs were found in the horizontal limb of the diagonal band.

Fig. 3c-d; Results, Main ITC nucleus

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Intercalated cell GABAergic neurons nt-y231zwbxhf projects to CEA (Central amygdalar nucleus) MBA:536 · Mouse

Main ITC terminals were consistently seen in the central amygdala along its anteroposterior axis.

Fig. 2b-c; Results, Main ITC nucleus

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Intercalated cell GABAergic neurons nt-y231zwbxhf projects to COApl (Cortical amygdalar area, posterior part, lateral zone) MBA:655 · Mouse

The posterolateral cortical amygdala received a very light lateral ITC projection.

Fig. 6; Results, Lateral ITCs

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Intercalated cell GABAergic neurons nt-y231zwbxhf projects to MEA (Medial amygdalar nucleus) MBA:403 · Mouse

Lateral ITCs sent a very light projection to the anterior medial amygdala.

Fig. 6; Results, Lateral ITCs

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Intercalated cell GABAergic neurons nt-y231zwbxhf projects to AAA (Anterior amygdalar area) MBA:23 · Mouse

Dense axon fields from caudal ITCs were found in the anterior amygdaloid area of the caudal basal forebrain.

Fig. 4b-c; Results, Caudal ITCs

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Intercalated cell GABAergic neurons nt-y231zwbxhf projects to BLA (Basolateral amygdalar nucleus) MBA:295 · Mouse

Contrary to earlier suggestions, the authors saw very little sign of main ITC projections into the basolateral amygdala.

Results, Main ITC nucleus

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TEa (Temporal association areas) MBA:541 synapses onto Intercalated cell GABAergic neurons nt-y231zwbxhf · Mouse

Temporal association cortex contained presynaptic neurons to caudal ITCs.

Fig. 5c-d; Results, Caudal ITCs

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PL (Prelimbic area) MBA:972 synapses onto Intercalated cell GABAergic neurons nt-y231zwbxhf · Mouse

Prelimbic cortex had no presynaptic neurons labelled from main ITC starter cells.

Results, Main ITC nucleus

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ENTl (Entorhinal area, lateral part) MBA:918 synapses onto Intercalated cell GABAergic neurons nt-y231zwbxhf · Mouse

Dense presynaptic clusters labelled from lateral ITCs were seen in dorsolateral entorhinal cortex.

Fig. 7c-d; Results, Lateral ITCs

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PO (Posterior complex of the thalamus) MBA:1020 synapses onto Intercalated cell GABAergic neurons nt-y231zwbxhf · Mouse

Posterior thalamic complex neurons were labelled as inputs to caudal ITCs.

Fig. 5c-d; Results, Caudal ITCs

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Intercalated cell GABAergic neurons nt-y231zwbxhf projects to IA (Intercalated amygdalar nucleus) MBA:1105 · Mouse

Lateral ITCs projected almost only to other ITC clusters: mainly the main ITC nucleus, densely to the anterior ITCs, and with some axons into the medial ITCs.

Fig. 6b-c; Results, Lateral ITCs

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