Inputs to the Dorsal Striatum of the Mouse Reflect the Parallel Circuit Architecture of the Forebrain

MD (Mediodorsal nucleus of thalamus) MBA:362 projects to STRd (Striatum dorsal region) MBA:485 · Mouse

Anterior striatal injections labeled neurons in the mediodorsal thalamic nucleus.

Fig. 4A

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SNc (Substantia nigra, compact part) MBA:374 projects to STRd (Striatum dorsal region) MBA:485 · Mouse

Striatal bead injections intensely labeled putative dopaminergic SNc neurons, the predominant source of dopaminergic input; medial and lateral injections labeled non-overlapping sets.

Fig. 5A; Fig. 9C

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SSp-bfd (Primary somatosensory area, barrel field) MBA:329 projects to STRd (Striatum dorsal region) MBA:485 · Mouse

AAV-GFP in vibrissal S1 yielded a focal axonal projection to the dorsolateral posterior striatum, largely separate from the M1 projection and mainly ipsilateral.

Fig. 10C,D

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IAD (Interanterodorsal nucleus of the thalamus) MBA:1113 projects to STRd (Striatum dorsal region) MBA:485 · Mouse

Interanterodorsal thalamic neurons were labeled after anterior dorsal striatal injections.

Fig. 4A

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Isocortex MBA:315 projects to STRd (Striatum dorsal region) MBA:485 · Mouse

Fluorescent bead injections into dorsal striatum labeled many neurons in deep layers (mainly layer V) across frontal, parietal sensory and motor cortex, with more labeling ipsilaterally.

Figs. 1, 3; Table 1

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MOp (Primary motor area) MBA:985 projects to TH (Thalamus) MBA:549 · Mouse

M1 axons labeled by AAV-GFP were seen terminating densely in the thalamus at a posterior coronal plane.

Fig. 10B

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BLA (Basolateral amygdalar nucleus) MBA:295 projects to STRd (Striatum dorsal region) MBA:485 · Mouse

Injections across dorsal (especially dorsomedial) striatum gave intense labeling of basolateral amygdala neurons.

Fig. 6A,B

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PO (Posterior complex of the thalamus) MBA:1020 projects to STRd (Striatum dorsal region) MBA:485 · Mouse

Posterior striatal injections predominantly labeled neurons in the posterior thalamic nucleus, and cannula controls argued against cortical leakage.

Fig. 4B,C; Results

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RE (Nucleus of reuniens) MBA:181 projects to STRd (Striatum dorsal region) MBA:485 · Mouse

Neurons in nucleus reuniens were retrogradely labeled from anterior dorsal striatal injections.

Fig. 4A

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CEA (Central amygdalar nucleus) MBA:536 projects to STRd (Striatum dorsal region) MBA:485 · Mouse

Central amygdala neurons were intensely labeled after tracer injections into many dorsal striatal sites.

Fig. 6A,B

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PO (Posterior complex of the thalamus) MBA:1020 projects to STRd (Striatum dorsal region) MBA:485 · Mouse

AAV-GFP infection of posterior lateral thalamus revealed axon collaterals leaving the internal capsule to branch with varicosities in a band of posterior dorsolateral striatum.

Fig. 8C-E

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AM (Anteromedial nucleus) MBA:127 projects to STRd (Striatum dorsal region) MBA:485 · Mouse

Anteromedial thalamic neurons were labeled following anterior dorsal striatal injections.

Fig. 4A

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LP (Lateral posterior nucleus of the thalamus) MBA:218 projects to STRd (Striatum dorsal region) MBA:485 · Mouse

Labeled cells in the mediorostral lateral posterior thalamus were seen after anterior striatal injections.

Fig. 4A

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CNU (Cerebral nuclei) MBA:623 projects to STRd (Striatum dorsal region) MBA:485 · Mouse

Many anterior dorsal striatal injections clearly labeled somata in the IPAC of the extended amygdala.

Fig. 6C,D

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CS (Superior central nucleus raphe) MBA:679 projects to STRd (Striatum dorsal region) MBA:485 · Mouse

Neurons of the medial raphe were commonly labeled by dorsal striatal tracer injections (data not shown).

Fig. 7 caption; Results

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VTA (Ventral tegmental area) MBA:749 projects to STRd (Striatum dorsal region) MBA:485 · Mouse

Dopaminergic neurons in the VTA were also retrogradely labeled from dorsal striatum, though fewer than in SNc.

Results, qualitative description; Fig. 2

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TH (Thalamus) MBA:549 projects to STRd (Striatum dorsal region) MBA:485 · Mouse

Labeled somata were found in the lateral geniculate nucleus after dorsal striatal tracer injections.

Results, thalamus paragraph; Table 1

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AD (Anterodorsal nucleus) MBA:64 projects to STRd (Striatum dorsal region) MBA:485 · Mouse

Anterodorsal thalamic neurons were labeled after anterior dorsal striatal injections.

Fig. 4A

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ILA (Infralimbic area) MBA:44 projects to STRd (Striatum dorsal region) MBA:485 · Mouse

In dual-color injections, the infralimbic cortex was labeled from the medial striatal injection site.

Fig. 9A

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PVT (Paraventricular nucleus of the thalamus) MBA:149 projects to STRd (Striatum dorsal region) MBA:485 · Mouse

Anterior striatal injections labeled cells in the paraventricular thalamic nucleus.

Fig. 4A

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ILM (Intralaminar nuclei of the dorsal thalamus) MBA:51 projects to STRd (Striatum dorsal region) MBA:485 · Mouse

Retrograde tracer in dorsal striatum showed the thalamic intralaminar nuclei to be a major source of striatal-projecting neurons.

Fig. 4; Results, qualitative description

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PO (Posterior complex of the thalamus) MBA:1020 projects to SSp (Primary somatosensory area) MBA:322 · Mouse

Thalamic AAV-GFP infection produced a dense columnar axonal plexus in layer IV of primary somatosensory cortex.

Fig. 8B

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) is unsure. “The layer IV columnar plexus is attributed to the posterior and ventral posterior thalamus together, so it cannot be assigned to PO alone.”

MO (Somatomotor areas) MBA:500 projects to STRd (Striatum dorsal region) MBA:485 · Mouse

In dual-color injections, agranular motor cortex was labeled from the lateral striatal injection site.

Fig. 9A

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Eth (Ethmoid nucleus of the thalamus) MBA:560581551 projects to STRd (Striatum dorsal region) MBA:485 · Mouse

Posterior dorsal striatal injections labeled neurons in the ethmoid thalamic nucleus.

Fig. 4B,C; Results

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CM (Central medial nucleus of the thalamus) MBA:599 projects to STRd (Striatum dorsal region) MBA:485 · Mouse

CM thalamic neurons were retrogradely labeled after dorsal striatal bead injections, particularly from anterior sites.

Fig. 4A; Results

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DR (Dorsal nucleus raphe) MBA:872 projects to STRd (Striatum dorsal region) MBA:485 · Mouse

Striatal injections labeled large putative serotonergic neurons in the dorsal raphe, less prominently than other inputs.

Fig. 7A,B

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RR (Midbrain reticular nucleus, retrorubral area) MBA:246 projects to STRd (Striatum dorsal region) MBA:485 · Mouse

Posterior striatal injections produced intense somatic labeling in the retrorubral nucleus.

Fig. 5

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MG (Medial geniculate complex) MBA:475 projects to STRd (Striatum dorsal region) MBA:485 · Mouse

Retrograde labeling from dorsal striatum was reliably found in the medial geniculate nucleus.

Results, thalamus paragraph; Table 1

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MOp (Primary motor area) MBA:985 projects to STRd (Striatum dorsal region) MBA:485 · Mouse

AAV-GFP in vibrissal M1 produced substantial axon arborization in anterior striatum plus fibers extending caudally along the dorsolateral striatum, terminating densely there.

Fig. 10A,B

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PF (Parafascicular nucleus) MBA:930 projects to STRd (Striatum dorsal region) MBA:485 · Mouse

Neurons in the parafascicular nucleus were reliably retrogradely labeled from striatal injections, especially more medial posterior sites.

Fig. 4; Results

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