Amygdaloid projections to the ventral striatum in mice: direct and indirect chemosensory inputs to the brain reward system

COApl (Cortical amygdalar area, posterior part, lateral zone) MBA:655 projects to LA (Lateral amygdalar nucleus) MBA:131 · Mouse

Labeling from posterolateral cortical amygdala injections continued from the lateral basal nucleus into the ventrolateral lateral nucleus.

Fig. 5B

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PA (Posterior amygdalar nucleus) MBA:780 projects to ACB (Nucleus accumbens) MBA:56 · Mouse

After accumbens injections, retrogradely labeled cells appeared in the medial and lateral amygdalohippocampal area: few after shell injections, many in the lateral part after core injections.

Table 1; Fig. 2D,E

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COApm (Cortical amygdalar area, posterior part, medial zone) MBA:663 projects to ACB (Nucleus accumbens) MBA:56 · Mouse

Injections that included the rostral edge of the medial shell labeled a few neurons in the deep posteromedial cortical amygdaloid nucleus.

Table 1; Fig. 2E

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PAA (Piriform-amygdalar area) MBA:788 projects to ACB (Nucleus accumbens) MBA:56 · Mouse

After shell injections, a few retrogradely labeled cells were found in the caudal amygdalopiriform transition area.

Fig. 2E; Table 1

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COApm (Cortical amygdalar area, posterior part, medial zone) MBA:663 projects to BLA (Basolateral amygdalar nucleus) MBA:295 · Mouse

Only scattered labeled fibers reached the basal nucleus after posteromedial cortical amygdala injections.

Fig. 5A

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BLAp (Basolateral amygdalar nucleus, posterior part) MBA:311 projects to ACB (Nucleus accumbens) MBA:56 · Mouse

Posterior basal nucleus injections produced extremely dense labeling in the caudomedial accumbens core and very dense, patchy labeling in the medial shell. Lateral shell labeling was diffuse.

Fig. 6D,E; Table 2

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MEA (Medial amygdalar nucleus) MBA:403 projects to OT (Olfactory tubercle) MBA:754 · Mouse

After the tubercle fluorogold injection, labeled cells appeared in the medial amygdala, restricted to its anterior part.

Fig. 3B

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BLAa (Basolateral amygdalar nucleus, anterior part) MBA:303 projects to OT (Olfactory tubercle) MBA:754 · Mouse

The anterior basal nucleus injection gave dense to very dense labeling in tubercle layers 2 and 3 and extremely dense labeling in the lateral cell bridges. The islands of Calleja were nearly unlabeled.

Fig. 6B,C; Table 3

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NLOT (Nucleus of the lateral olfactory tract) MBA:619 projects to OT (Olfactory tubercle) MBA:754 · Mouse

A fluorogold injection in the ventromedial olfactory tubercle retrogradely labeled neurons in layers 2 and 3 of the nucleus of the lateral olfactory tract.

Fig. 3; Table 1

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BLAp (Basolateral amygdalar nucleus, posterior part) MBA:311 projects to OT (Olfactory tubercle) MBA:754 · Mouse

The posterior part of the basal nucleus held abundant fluorogold-labeled cells after the tubercle injection.

Fig. 3C,D

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BMAa (Basomedial amygdalar nucleus, anterior part) MBA:327 projects to BST (Bed nuclei of the stria terminalis) MBA:351 · Mouse

Thick labeled fibers from the anterior accessory basal injection ran in the stria terminalis to terminal fields in the bed nucleus of the stria terminalis.

Results, injections in the accessory basal nucleus (not shown)

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BMAp (Basomedial amygdalar nucleus, posterior part) MBA:334 projects to OT (Olfactory tubercle) MBA:754 · Mouse

Posterior accessory basal injections labeled layers 2, 3 and 1b of the central tubercle, with a few fibers along the edges of islands of Calleja and the major island.

Fig. 7C,D; Table 3

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LA (Lateral amygdalar nucleus) MBA:131 projects to OT (Olfactory tubercle) MBA:754 · Mouse

After small rostral lateral nucleus injections, tubercle labeling was particularly dense, mainly in layer 3, and was associated with the most medial islands of Calleja but not the major island.

Fig. 8B-E; Table 3

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BLAa (Basolateral amygdalar nucleus, anterior part) MBA:303 projects to NLOT (Nucleus of the lateral olfactory tract) MBA:619 · Mouse

Labeled fibers from the anterior basal nucleus injection traveled rostrally in the longitudinal association bundle and innervated the nucleus of the lateral olfactory tract.

Results, injections in the basal nucleus

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BLAp (Basolateral amygdalar nucleus, posterior part) MBA:311 projects to OT (Olfactory tubercle) MBA:754 · Mouse

After posterior basal nucleus injections, labeled fibers reached the medialmost tubercle (deep layer 1 and layers 2 and 3) through the medial cell bridges. A few fibers entered the medial islands of Calleja.

Fig. 6E; Table 3

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COA (Cortical amygdalar area) MBA:631 projects to AON (Anterior olfactory nucleus) MBA:159 · Mouse

Anterograde labeling from the CxA/COAa injection extended as far as the medial anterior olfactory nucleus.

Results, anterior cortical amygdala injection (not shown)

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COApl (Cortical amygdalar area, posterior part, lateral zone) MBA:655 projects to OT (Olfactory tubercle) MBA:754 · Mouse

The posterolateral cortical amygdala injection labeled the tubercle, cell bridges and islands of Calleja in the same pattern as posteromedial injections, but less densely.

Table 3; Results

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COApm (Cortical amygdalar area, posterior part, medial zone) MBA:663 projects to OT (Olfactory tubercle) MBA:754 · Mouse

After posteromedial cortical amygdala injections, the densest ventral striatal terminal fields were in the cell bridges and caudomedial tubercle layer 3, closely associated with the islands of Calleja, including the major island.

Fig. 4B-E; Table 3

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COApl (Cortical amygdalar area, posterior part, lateral zone) MBA:655 projects to OT (Olfactory tubercle) MBA:754 · Mouse

A tubercle fluorogold injection retrogradely labeled neurons in the posterolateral cortical amygdaloid nucleus.

Fig. 3C,D

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COA (Cortical amygdalar area) MBA:631 projects to LA (Lateral amygdalar nucleus) MBA:131 · Mouse

The CxA injection also gave moderately dense anterograde labeling in the ventrolateral lateral nucleus.

Fig. 5C

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BLAv (Basolateral amygdalar nucleus, ventral part) MBA:451 projects to ACB (Nucleus accumbens) MBA:56 · Mouse

Accumbens shell and core injections retrogradely labeled neurons in the region tentatively identified as the ventral basal nucleus.

Table 1; Fig. 2B

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BMAp (Basomedial amygdalar nucleus, posterior part) MBA:334 projects to ACB (Nucleus accumbens) MBA:56 · Mouse

Small injections in the posterior accessory basal nucleus produced a moderately dense terminal field in the whole accumbens core and the ventral medial shell. Lateral shell labeling was less dense, and labeling was also present contralaterally.

Fig. 7C,D; Table 2

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COA (Cortical amygdalar area) MBA:631 projects to ACB (Nucleus accumbens) MBA:56 · Mouse

BDA in the cortex-amygdala transition zone and lateral COAa labeled the accumbens along its whole rostrocaudal extent. It formed three main shell terminal fields and a dense field in the caudal core, bilaterally with ipsilateral dominance.

Fig. 4F-H; Table 2

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BMAa (Basomedial amygdalar nucleus, anterior part) MBA:327 projects to NDB (Diagonal band nucleus) MBA:596 · Mouse

Fibers from the anterior accessory basal injection formed a dense terminal meshwork in the horizontal limb of the diagonal band.

Fig. 7B

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CEA (Central amygdalar nucleus) MBA:536 projects to ACB (Nucleus accumbens) MBA:56 · Mouse

No accumbens injection retrogradely labeled any cells in the central amygdala.

Results, retrograde labeling after Acb injections

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PA (Posterior amygdalar nucleus) MBA:780 projects to NDB (Diagonal band nucleus) MBA:596 · Mouse

Fibers from the lateral amygdalohippocampal area injection ran in the longitudinal association bundle and innervated the horizontal limb of the diagonal band.

Results, injection in the amygdalohippocampal area

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MEA (Medial amygdalar nucleus) MBA:403 projects to ACB (Nucleus accumbens) MBA:56 · Mouse

The medial amygdala was unlabeled after accumbens injections. The single exception was an injection that also involved the ventral septum.

Results, retrograde labeling after Acb injections

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BMAa (Basomedial amygdalar nucleus, anterior part) MBA:327 projects to OT (Olfactory tubercle) MBA:754 · Mouse

The anterior accessory basal injection labeled all three layers of the medial tubercle and the medialmost cell bridges. A few fibers entered islands of Calleja and surrounded the major island; tubercle labeling was described as scarce overall.

Fig. 7B; Table 3

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BMAa (Basomedial amygdalar nucleus, anterior part) MBA:327 projects to ACB (Nucleus accumbens) MBA:56 · Mouse

An injection in the rostral anterior accessory basal nucleus gave scarce accumbens labeling: fields in the dorsolateral caudal core and caudal lateral shell, and scarce fibers in the ventral medial shell.

Fig. 7B; Table 2

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BLAa (Basolateral amygdalar nucleus, anterior part) MBA:303 projects to OT (Olfactory tubercle) MBA:754 · Mouse

The anterior basal nucleus was almost entirely free of retrograde labeling after the ventromedial tubercle injection.

Results, olfactory tubercle injections

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BLAp (Basolateral amygdalar nucleus, posterior part) MBA:311 projects to BST (Bed nuclei of the stria terminalis) MBA:351 · Mouse

Posterior basal nucleus injections produced a dense terminal field in the bed nucleus of the stria terminalis.

Results, injections in the basal nucleus (not shown)

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PA (Posterior amygdalar nucleus) MBA:780 projects to OT (Olfactory tubercle) MBA:754 · Mouse

The amygdalohippocampal area showed abundant retrograde labeling after the tubercle injection.

Fig. 3C,D

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COApm (Cortical amygdalar area, posterior part, medial zone) MBA:663 projects to LA (Lateral amygdalar nucleus) MBA:131 · Mouse

Posteromedial cortical amygdala injections left sparse labeled fibers in the lateral nucleus.

Results, intra-amygdaloid projections

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COApl (Cortical amygdalar area, posterior part, lateral zone) MBA:655 projects to BLA (Basolateral amygdalar nucleus) MBA:295 · Mouse

Posterolateral cortical amygdala injections gave moderate-to-dense anterograde labeling in the basal nucleus, mostly in a band along its lateral part.

Fig. 5B

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LA (Lateral amygdalar nucleus) MBA:131 projects to CP (Caudoputamen) MBA:672 · Mouse

The dense core terminal field from lateral nucleus injections extended into the adjacent ventralmost caudate-putamen.

Fig. 8; Table 2

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COApm (Cortical amygdalar area, posterior part, medial zone) MBA:663 projects to ACB (Nucleus accumbens) MBA:56 · Mouse

BDA injected into the posteromedial cortical amygdala labeled fibers in the ventral accumbens core and sparse fibers across most of the shell. Dense terminal fields lay in the caudoventral lateral shell and the ventral medial shell.

Fig. 4C-E; Table 2

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BMAa (Basomedial amygdalar nucleus, anterior part) MBA:327 projects to PALv (Pallidum, ventral region) MBA:835 · Mouse

Labeled fibers in the ansa peduncularis from the anterior accessory basal injection reached the ventral pallidum.

Fig. 7B

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COA (Cortical amygdalar area) MBA:631 projects to OT (Olfactory tubercle) MBA:754 · Mouse

This injection densely labeled all three layers across the whole mediolateral extent of the tubercle, with no obvious association with the islands of Calleja.

Fig. 4G; Table 3

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PA (Posterior amygdalar nucleus) MBA:780 projects to ACB (Nucleus accumbens) MBA:56 · Mouse

An injection restricted to the lateral amygdalohippocampal area gave moderately dense labeling in the ventral accumbens core and parts of the medial shell. The midcaudal lateral shell was sparsely labeled.

Fig. 7E,F; Table 2

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PA (Posterior amygdalar nucleus) MBA:780 projects to OT (Olfactory tubercle) MBA:754 · Mouse

The lateral amygdalohippocampal area injection labeled all three tubercle layers, mainly medially, with dense terminal fields closely associated with the medial islands of Calleja and the major island.

Fig. 7F; Table 3

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PIR (Piriform area) MBA:961 projects to OT (Olfactory tubercle) MBA:754 · Mouse

The posterior piriform cortex was densely labeled retrogradely by the tubercle fluorogold injection.

Fig. 3C,D

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COApm (Cortical amygdalar area, posterior part, medial zone) MBA:663 projects to OT (Olfactory tubercle) MBA:754 · Mouse

A tubercle fluorogold injection retrogradely labeled neurons in the posteromedial cortical amygdaloid nucleus.

Fig. 3C,D

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COAa (Cortical amygdalar area, anterior part) MBA:639 projects to ACB (Nucleus accumbens) MBA:56 · Mouse

Accumbens shell injections retrogradely labeled a few cells in the anterior cortical amygdaloid nucleus.

Table 1; Fig. 2B

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BLAa (Basolateral amygdalar nucleus, anterior part) MBA:303 projects to ACB (Nucleus accumbens) MBA:56 · Mouse

BDA restricted to the medial anterior basal nucleus produced dense, patchy terminal fields in all accumbens divisions, very dense in the lateral half, plus weaker contralateral labeling.

Fig. 6B,C; Table 2

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COAa (Cortical amygdalar area, anterior part) MBA:639 projects to OT (Olfactory tubercle) MBA:754 · Mouse

Fluorogold injected into the olfactory tubercle labeled neurons in layers 2 and 3 of the anterior cortical amygdaloid nucleus.

Fig. 3B

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LA (Lateral amygdalar nucleus) MBA:131 projects to ACB (Nucleus accumbens) MBA:56 · Mouse

Lateral nucleus injections produced the densest ventral striatal terminal field in the accumbens core, plus a conspicuous field in the ventral shell and a moderate-to-dense field in the midcaudal lateral shell. The dorsal medial shell was nearly unlabeled, and labeling was bilateral with ipsilateral dominance.

Fig. 8B-E; Table 2

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COApl (Cortical amygdalar area, posterior part, lateral zone) MBA:655 projects to ACB (Nucleus accumbens) MBA:56 · Mouse

A restricted injection in the posterolateral cortical amygdala produced sparse labeled fibers in the medial caudal accumbens core and only a few fibers in the shell.

Table 2; Results

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COApm (Cortical amygdalar area, posterior part, medial zone) MBA:663 projects to BMA (Basomedial amygdalar nucleus) MBA:319 · Mouse

Posteromedial cortical amygdala injections produced anterograde labeling in the accessory basal nucleus, dense in its posterior part.

Fig. 5A

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NLOT (Nucleus of the lateral olfactory tract) MBA:619 projects to ACB (Nucleus accumbens) MBA:56 · Mouse

A lateral shell injection labeled cells in layers 2 and 3 of the nucleus of the lateral olfactory tract. Core injections labeled a few cells bilaterally in its layer 3.

Fig. 2F; Table 1

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COA (Cortical amygdalar area) MBA:631 projects to OT (Olfactory tubercle) MBA:754 · Mouse

The tubercle fluorogold injection also labeled a number of cells in the cortex-amygdala transition zone.

Results, olfactory tubercle injections

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