A discrete dopaminergic projection from the incertohypothalamic A13 cell group to the dorsolateral periaqueductal gray in rat

ZI (Zona incerta) UBERON:0001907 projects to PAG (Periaqueductal gray) UBERON:0003040 · Rat

BDA injected into the medial zona incerta, covering A13 TH-positive neurons, produced BDA/TH double-labelled axons and boutons in the dlPAG. This confirms the retrograde result.

Results, Dopaminergic projection from A13 to the dlPAG; Figs. 6-7

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HY (Hypothalamus) UBERON:0001898 projects to PAG (Periaqueductal gray) UBERON:0003040 · Rat

CTb/TH double-labelled neurons were found in the A11 group, both ipsilateral and contralateral, after dlPAG injections. In some cases A11 was the second largest source.

Results, A11 cell group; Table 1; Fig. 4

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PH (Posterior hypothalamic nucleus) UBERON:0002706 projects to PAG (Periaqueductal gray) UBERON:0003040 · Rat

TH-positive neurons retrogradely labelled from the dlPAG lay in the posterior hypothalamic area, one of three extended A10 sites. The A10 group as a whole supplied 22-30% of double-labelled cells in three cases.

Results, A10 cell group; Fig. 5A

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ZI (Zona incerta) UBERON:0001907 projects to SC (superior colliculus) UBERON:0001945 · Rat

A control CTb injection confined to the deep superior colliculus yielded only about 6 double-labelled neurons in total, split equally between A13 and A10.

Results, Control case (R29)

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RL (Rostral linear nucleus raphe) UBERON:0013734 projects to PAG (Periaqueductal gray) UBERON:0003040 · Rat

CTb injections in the dlPAG retrogradely labelled TH-positive neurons in the rostral linear raphe nucleus, part of the extended A10 group.

Results, A10 cell group; Fig. 5B,C

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SNc (Substantia nigra, compact part) UBERON:0001965 projects to PAG (Periaqueductal gray) UBERON:0003040 · Rat

Very few CTb/TH double-labelled cells appeared in A9 (substantia nigra), and only in two cases whose injections spread into the intermediate-caudal dlPAG and the superior colliculus.

Results, Other cell groups; Table 1

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HY (Hypothalamus) UBERON:0001898 projects to PAG (Periaqueductal gray) UBERON:0003040 · Rat

Very few double-labelled neurons were seen in the A15 group, and only in cases R23 and R26.

Results, Other cell groups; Table 1

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ZI (Zona incerta) UBERON:0001907 projects to PAG (Periaqueductal gray) UBERON:0003040 · Rat

After CTb injections into the dlPAG, the A13 group in the medial zona incerta held the most CTb/TH double-labelled neurons of any dopaminergic group in every case. They were mostly ipsilateral and concentrated in the intermediate A13.

Results, A13 cell group; Table 1; Fig. 3

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PVZ (Periventricular zone) UBERON:0002271 projects to PAG (Periaqueductal gray) UBERON:0003040 · Rat

CTb/TH double-labelled neurons were observed in the A14 group in every dlPAG case except R30.

Results, Other cell groups; Table 1

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VTA (Ventral tegmental area) UBERON:0002691 projects to PAG (Periaqueductal gray) UBERON:0003040 · Rat

No retrogradely labelled neurons were found in the ventral tegmental area after CTb injection into the dlPAG.

Results, A10 cell group

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