Reorganization of Basolateral Amygdala-Subiculum Circuitry in Mouse Epilepsy Model

BLA (Basolateral amygdalar nucleus) MBA:295 projects to SUB (Subiculum) MBA:502 · Mouse

After iontophoretic PHA-L injections into the BLA, labelled fibres and terminal-like swellings appeared in the ventral subiculum of both control and pilocarpine-epileptic mice. The swellings lay apposed to calbindin-, calretinin- and parvalbumin-positive vSub neurons. Terminal-like density was about 4476/mm2 in controls and about 6019/mm2 in epileptic mice, a 25.63% increase.

Fig. 2A–L; Results, 'Pathological Changes of Afferent and Efferent Pathways from the BLA'

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

SUB (Subiculum) MBA:502 projects to BLA (Basolateral amygdalar nucleus) MBA:295 · Mouse

CTB injected into the BLA retrogradely labelled neurons, chiefly in the ipsilateral ventral subiculum, in both control and epileptic mice. The density of labelled vSub neurons did not differ significantly between the two groups.

Fig. 2M–O; Results, 'Pathological Changes of Afferent and Efferent Pathways from the BLA'

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.