Journal article
Monosynaptic Projections to Excitatory and Inhibitory preBötzinger Complex Neurons
Frontiers in Neuroanatomy, 2020
DOI 10.3389/fnana.2020.00058 · PubMed 33013329 · PMC7507425Licence: CC-BY-4.0
37 claims from this source
SNc (Substantia nigra, compact part) MBA:374 projects to MY (Medulla) MBA:354 · Mouse
Fluorogold injected into the preBötC retrogradely labelled neurons in the substantia nigra.
Supplementary Figures S1B–P
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sAMY (Striatum-like amygdalar nuclei) MBA:278 projects to MY (Medulla) MBA:354 · Mouse
Amygdalar neurons were retrogradely labelled following unilateral Fluorogold injection into the preBötC and surrounding tissue.
Supplementary Figures S1B–P
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VMH (Ventromedial hypothalamic nucleus) MBA:693 synapses onto MY (Medulla) MBA:354 · Mouse
A few labelled presynaptic neurons were found in the ventromedial hypothalamic nucleus in 2 of 5 SST-Cre and 2 of 4 GlyT2-Cre rabies experiments.
Figures 4D,J
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PAG (Periaqueductal gray) MBA:795 synapses onto MY (Medulla) MBA:354 · Mouse
Presynaptic rabies-labelled neurons were present in the dorsolateral periaqueductal gray of both SST-Cre and GlyT2-Cre mice, mainly contralateral to the preBötC injection.
Figures 3A,E
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AVPV (Anteroventral periventricular nucleus) MBA:272 synapses onto MY (Medulla) MBA:354 · Mouse
A small number of presynaptic neurons were labelled in the anteroventral periventricular hypothalamic nucleus after monosynaptic rabies tracing from preBötC neurons.
Results, suprapontine projections (data not shown)
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SCm (Superior colliculus, motor related) MBA:294 synapses onto MY (Medulla) MBA:354 · Mouse
Monosynaptic rabies tracing from excitatory SST+ and inhibitory GlyT2+ preBötC neurons labelled neurons in the superior colliculus bilaterally, with a contralateral predominance.
Figures 3B,F
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MOp5 (Primary motor area, Layer 5) MBA:648 synapses onto MY (Medulla) MBA:354 · Mouse
Monosynaptically labelled neurons were found in layer 5 (likely 5B) of primary motor cortex, scattered along the rostrocaudal axis and present bilaterally with an ipsilateral bias; cortical labelling occurred in 3 of 5 SST-Cre and 1 of 4 GlyT2-Cre mice.
Figures 4E,K
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KF (Koelliker-Fuse subnucleus) MBA:123 synapses onto MY (Medulla) MBA:354 · Mouse
Rabies-labelled presynaptic neurons were found in the Kölliker-Fuse subnucleus for both the SST+ and GlyT2+ preBötC starter populations.
Figures 2E,J
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DR (Dorsal nucleus raphe) MBA:872 synapses onto MY (Medulla) MBA:354 · Mouse
Rarely (2 of 5 SST-Cre and 1 of 4 GlyT2-Cre mice), rabies-labelled presynaptic neurons were seen in the dorsal raphe nucleus.
Figures 3D,H
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KF (Koelliker-Fuse subnucleus) MBA:123 projects to MY (Medulla) MBA:354 · Mouse
Fluorogold injection into the preBötC labelled neurons in the Kölliker-Fuse nucleus.
Supplementary Figures S1B–P
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BST (Bed nuclei of the stria terminalis) MBA:351 synapses onto MY (Medulla) MBA:354 · Mouse
Rabies-labelled presynaptic neurons were detected in the bed nucleus of the stria terminalis in 2 of 5 SST-Cre and 1 of 4 GlyT2-Cre preBötC tracing experiments.
Results, suprapontine projections
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DMH (Dorsomedial nucleus of the hypothalamus) MBA:830 synapses onto MY (Medulla) MBA:354 · Mouse
Presynaptic neurons were labelled in the dorsomedial hypothalamic nucleus after monosynaptic rabies tracing from excitatory and inhibitory preBötC neurons.
Figures 4C,I
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IC (Inferior colliculus) MBA:4 synapses onto MY (Medulla) MBA:354 · Mouse
In the same sections where collicular labelling was examined, no rabies-labelled presynaptic neurons were found in the inferior colliculus for either preBötC subpopulation.
Figures 3B,F
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RN (Red nucleus) MBA:214 synapses onto MY (Medulla) MBA:354 · Mouse
In a subset of experiments (3 of 5 SST-Cre and 3 of 4 GlyT2-Cre mice), neurons of the lateral magnocellular red nucleus were retrogradely labelled by monosynaptic rabies from preBötC starter cells.
Figures 3C,G
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PHY (Perihypoglossal nuclei) MBA:154 synapses onto MY (Medulla) MBA:354 · Mouse
Presynaptic rabies-labelled neurons were detected in the parahypoglossal region in both SST-Cre and GlyT2-Cre tracing experiments.
Figures 2D,I
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ARH (Arcuate hypothalamic nucleus) MBA:223 synapses onto MY (Medulla) MBA:354 · Mouse
Monosynaptic rabies tracing labelled a few arcuate hypothalamic neurons presynaptic to both excitatory and inhibitory preBötC neurons.
Figures 4B,H
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PB (Parabrachial nucleus) MBA:867 synapses onto MY (Medulla) MBA:354 · Mouse
Within the pons, monosynaptically labelled neurons were seen in the dorsolateral and medial parabrachial nuclei after rabies tracing from SST+ and from GlyT2+ preBötC neurons.
Figures 2E,J
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IRN (Intermediate reticular nucleus) MBA:136 synapses onto MY (Medulla) MBA:354 · Mouse
Rabies-labelled presynaptic cells were distributed throughout the intermediate reticular nucleus, including the region dorsomedial to the Bötzinger Complex described as the pre-inspiratory complex, for both excitatory and inhibitory preBötC starter cells.
Figure 2D and Results (data not shown)
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PVH (Paraventricular hypothalamic nucleus) MBA:38 synapses onto MY (Medulla) MBA:354 · Mouse
Retrogradely labelled presynaptic neurons were seen in the paraventricular hypothalamic nucleus in 2 of 5 SST-Cre and 2 of 4 GlyT2-Cre mice.
Figures 4D,J
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MPO (Medial preoptic area) MBA:523 synapses onto MY (Medulla) MBA:354 · Mouse
Small numbers of rabies-labelled presynaptic neurons were observed in the medial preoptic area for both preBötC starter populations.
Results, suprapontine projections (Figure 4)
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VII (Facial motor nucleus) MBA:661 projects to MY (Medulla) MBA:354 · Mouse
Fluorogold deposited in the preBötC retrogradely labelled neurons in the facial nucleus.
Supplementary Figures S1B–P
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CNU (Cerebral nuclei) MBA:623 synapses onto MY (Medulla) MBA:354 · Mouse
Presynaptic rabies-labelled cells were occasionally found in the basal forebrain (1 of 5 SST-Cre and 1 of 4 GlyT2-Cre mice).
Results, suprapontine projections (data not shown)
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SSp (Primary somatosensory area) MBA:322 synapses onto MY (Medulla) MBA:354 · Mouse
Presynaptic rabies-labelled neurons were also observed in apparent layers 4 and 5 of primary somatosensory cortex corresponding to hindlimb and forelimb representations.
Figures 4E,K; Results, suprapontine projections
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LHA (Lateral hypothalamic area) MBA:194 synapses onto MY (Medulla) MBA:354 · Mouse
Rabies-labelled presynaptic cells were found in the lateral hypothalamus of both SST-Cre and GlyT2-Cre mice injected in the preBötC.
Figures 4C,I
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ZI (Zona incerta) MBA:797 synapses onto MY (Medulla) MBA:354 · Mouse
A small number of presynaptic rabies-labelled neurons (fewer than 20 per identified region rostral to the midbrain) were found in the zona incerta for both SST+ and GlyT2+ preBötC starter populations.
Figures 4A,G
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CEA (Central amygdalar nucleus) MBA:536 synapses onto MY (Medulla) MBA:354 · Mouse
Sparse but consistent rabies labelling confined to the central nucleus of the amygdala was seen after tracing from preBötC starter cells (4 of 5 SST-Cre and 2 of 4 GlyT2-Cre mice), bilaterally with more cells ipsilateral to the injection.
Figures 4F,L
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RN (Red nucleus) MBA:214 projects to MY (Medulla) MBA:354 · Mouse
Retrogradely labelled cells were present in the red nucleus after Fluorogold deposition in the preBötC.
Supplementary Figures S1B–P
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MOp (Primary motor area) MBA:985 projects to MY (Medulla) MBA:354 · Mouse
Retrograde labelling in motor cortex followed Fluorogold injection into the preBötC region.
Supplementary Figures S1B–P
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SNc (Substantia nigra, compact part) MBA:374 synapses onto MY (Medulla) MBA:354 · Mouse
On rare occasions (2 of 5 SST-Cre and 1 of 4 GlyT2-Cre mice), labelled cells were found in or at the border of the substantia nigra pars compacta after monosynaptic rabies tracing from preBötC neurons.
Figures 3D,H
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NTS (Nucleus of the solitary tract) MBA:651 synapses onto MY (Medulla) MBA:354 · Mouse
mCherry-only neurons in the nucleus of the solitary tract were found after monosynaptic rabies tracing from both SST+ and GlyT2+ preBötC neurons, indicating direct solitary tract input to both preBötC subpopulations.
Figures 2D,I
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XII (Hypoglossal nucleus) MBA:773 projects to MY (Medulla) MBA:354 · Mouse
Retrograde Fluorogold labelling from the preBötC was observed in the hypoglossal nucleus.
Supplementary Figures S1B–P
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P (Pons) MBA:771 synapses onto MY (Medulla) MBA:354 · Mouse
Occasional monosynaptically labelled neurons were observed in the pontine reticular nuclei in the rabies tracing experiments.
Results, brainstem afferents (Figure 2)
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PHY (Perihypoglossal nuclei) MBA:154 projects to MY (Medulla) MBA:354 · Mouse
Fluorogold injected into the preBötC produced retrogradely labelled cells in the parahypoglossal region.
Supplementary Figures S1B–P
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NTS (Nucleus of the solitary tract) MBA:651 projects to MY (Medulla) MBA:354 · Mouse
Neurons of the nucleus of the solitary tract were retrogradely labelled after Fluorogold injection into the preBötC and its immediate surround.
Supplementary Figures S1B–P
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