Inhibition of projections from the basolateral amygdala to the entorhinal cortex disrupts the acquisition of contextual fear

BLA glutamatergic principal neurons nt-wprma5fcrr functionally connects to ENT (Entorhinal area) MBA:909 · Mouse

In slices, blue-light stimulation of ChR2-expressing BLA terminals evoked excitatory postsynaptic currents in the great majority of recorded entorhinal cortex neurons (49 of 56), with no significant paired-pulse ratio change.

Fig. 1D,E; Results, 'Optogenetic targeting of glutamatergic terminals in the EC from the BLA'

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5) agrees.

BLA (Basolateral amygdalar nucleus) MBA:295 projects to ENT (Entorhinal area) MBA:909 · Mouse

After AAV-CaMKIIa-ChR2-eYFP injection into the BLA, eYFP-labelled cell bodies filled the BLA and eYFP-positive axonal fibers were seen in the entorhinal cortex, indicating an anterogradely traced BLA axonal projection to EC.

Fig. 1B,C; Results, 'Optogenetic targeting of glutamatergic terminals in the EC from the BLA'

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5) agrees.