Different forms of decision-making involve changes in the synaptic strength of the thalamic, hippocampal, and amygdalar afferents to the medial prefrontal cortex

MD (Mediodorsal nucleus of thalamus) MBA:362 functionally connects to PL (Prelimbic area) MBA:972 · Mouse

In chronically implanted behaving mice, electrical stimulation of the MD thalamus evoked field postsynaptic potentials in the medial prefrontal cortex. These potentials showed an input-output relation, paired-pulse facilitation peaking at 100 ms, and a delayed LTP after high-frequency stimulation.

Fig. 1B; Fig. 5A,D,G; Data collection and analysis

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) disagrees. “The 13.1 ± 1.2 ms value is the latency to peak amplitude of the first fPSP component, not a conduction delay; onset latencies are reported separately in Table 1.”

BLA (Basolateral amygdalar nucleus) MBA:295 functionally connects to PL (Prelimbic area) MBA:972 · Mouse

Electrical stimulation of the basolateral amygdala in behaving mice evoked field postsynaptic potentials in the medial prefrontal cortex. These potentials showed paired-pulse facilitation peaking at 40 ms and a fast-rising, long-lasting LTP after high-frequency stimulation.

Fig. 1D; Fig. 5C,F,I; Data collection and analysis

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) disagrees. “The 14.3 ± 1 ms value is a time-to-peak latency, so calling it a conduction delay misstates the measure; onset latencies are in Table 1.”

CA1 (Field CA1) MBA:382 functionally connects to PL (Prelimbic area) MBA:972 · Mouse

Electrical stimulation of the CA1 pyramidal layer in behaving mice evoked field postsynaptic potentials in the medial prefrontal cortex. These potentials showed a steep input-output curve, paired-pulse facilitation peaking at 40 ms, and a small, slowly developing LTP.

Fig. 1C; Fig. 5B,E,H; Data collection and analysis

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) disagrees. “The 15.4 ± 1.3 ms value is the latency of maximum fPSP amplitude, not a conduction delay, which would correspond to the onset latencies in Table 1.”