Synapsin I Controls Synaptic Maturation of Long-Range Projections in the Lateral Amygdala in a Targeted Selective Fashion

CTX (Cerebral cortex) MBA:688 functionally connects to LA (Lateral amygdalar nucleus) MBA:131 · Mouse

In dual recordings, external capsule stimulation evoked AMPA-receptor-mediated inward currents in GAD67-GFP interneurons of the lateral amygdala. Stimulation intensity was set to give about 100 pA in the interneuron.

Fig. 1C-D; Fig. 2B

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TH (Thalamus) MBA:549 functionally connects to LA glutamatergic principal neurons nt-659aayyts5 · Mouse

Stimulating thalamic fibres in the internal capsule evoked EPSCs in lateral amygdala principal neurons. These responses were larger than cortical responses at matched stimulation intensities, and the interneuron/principal-neuron ratio shifted toward principal neurons in adults.

Fig. 1E-F; Fig. 2D-E; Supplementary Fig. 1

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TH (Thalamus) MBA:549 functionally connects to LA (Lateral amygdalar nucleus) MBA:131 · Mouse

Internal capsule stimulation evoked excitatory currents in GAD67-GFP lateral amygdala interneurons recorded together with neighbouring principal neurons.

Fig. 1E; Fig. 2D; Supplementary Fig. 1

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LA (Lateral amygdalar nucleus) MBA:131 functionally connects to LA glutamatergic principal neurons nt-659aayyts5 · Mouse

Spikes evoked in GFP interneurons produced outward GABAergic currents in neighbouring principal neurons held at 0 mV in a subset of pairs. The connection rate did not differ significantly between juvenile and adult wild-type mice.

Fig. 3B-F; Results, 'The IN-PN Connectivity Remains Stable'

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CTX (Cerebral cortex) MBA:688 functionally connects to LA glutamatergic principal neurons nt-659aayyts5 · Mouse

Stimulating cortical fibres in the external capsule of acute slices evoked EPSCs in lateral amygdala principal neurons in juvenile and adult mice; under minimal stimulation, the excitatory drive onto these neurons increased with age.

Fig. 1C-D; Fig. 2B-C; Supplementary Fig. 1

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