A zona incerta-basomedial amygdala circuit modulates aversive expectation in emotional stress-induced aversive learning deficits

ZI (Zona incerta) MBA:797 projects to BMA (Basomedial amygdalar nucleus) MBA:319 · Mouse

Cre-dependent mCherry expressed selectively in tyrosine hydroxylase-positive cells of the zona incerta (via TH-Cre plus DIO-mCherry injection) produced mCherry-labelled axon terminals in the basomedial amygdala, showing an anterograde projection from ZI TH+ neurons to BMA.

Fig. 3A,B; Supplementary Fig. 5

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ZI (Zona incerta) MBA:797 synapses onto BMA (Basomedial amygdalar nucleus) MBA:319 · Mouse

Helper viruses (hSyn-Cre, DIO-RVG, DIO-TVA-EGFP) followed by pseudotyped G-deleted rabies virus injected into the basomedial amygdala produced DsRed-labelled presynaptic neurons in the zona incerta, confirming ZI input onto BMA neurons.

Supplementary Fig. 6 (described in Results, ZI-BMA circuit section)

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