Distinct Spatiotemporal Activation Patterns of the Perirhinal-Entorhinal Network in Response to Cortical and Amygdala Input

AIp (Agranular insular area, posterior part) MBA:111 functionally connects to ENTm (Entorhinal area, medial part, dorsal zone) MBA:926 · Mouse

In control ACSF, AiP-evoked activity did not reach the MEC in most slices. With GABAA receptors partly blocked by 1 uM bicuculline, AiP stimulation recruited the MEC last, after PER and LEC, in all slices and at all intensities.

Fig. 2G; Fig. 3A,B,E,G; Fig. 5A

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AIp (Agranular insular area, posterior part) MBA:111 projects to PERI (Perirhinal area) MBA:922 · Mouse

DiI placed in the AiP of slices produced only local staining in superficial AiP. No labelled projection to the PER/EC network was reported, which leaves this pathway unresolved by tracing.

Supplementary Fig. S2A

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LA (Lateral amygdalar nucleus) MBA:131 functionally connects to ENTl (Entorhinal area, lateral part) MBA:918 · Mouse

In control conditions, LA stimulation evoked LEC responses in only 2 of 9 slices. With bicuculline, LA stimulation activated the deep and then the superficial LEC layers after a delay, and latency fell as stimulus intensity rose.

Fig. 2G; Fig. 3C,D,F,G; Fig. 5D-F

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LA (Lateral amygdalar nucleus) MBA:131 functionally connects to PERI (Perirhinal area) MBA:922 · Mouse

In control conditions, LA stimulation evoked small, short-latency VSD responses confined to the deep PER layers in a subset of slices (6 of 9). Under bicuculline, activity started in deep PER about 50 ms after stimulation and then spread to superficial layers.

Fig. 2C,D,F,G; Fig. 3C,D,F,G; Supplementary Fig. S1C

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AIp (Agranular insular area, posterior part) MBA:111 functionally connects to PERI (Perirhinal area) MBA:922 · Mouse

In horizontal mouse slices imaged with voltage-sensitive dye, stimulating superficial AiP at 500 uA evoked responses that appeared first in the perirhinal cortex. This happened both in normal ACSF and with 1 uM bicuculline.

Fig. 2A,B,E,G; Fig. 3A,B,E,G

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LA (Lateral amygdalar nucleus) MBA:131 functionally connects to ENTm (Entorhinal area, medial part, dorsal zone) MBA:926 · Mouse

Under 1 uM bicuculline, LA stimulation recruited first the deep and then the superficial MEC layers, after the PER and LEC. Superficial MEC responded significantly later than deep MEC.

Fig. 3C,D,F,G; Fig. 6C,D

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LA (Lateral amygdalar nucleus) MBA:131 projects to PERI (Perirhinal area) MBA:922 · Mouse

DiI crystals placed in the LA of horizontal slices labelled a projection reaching the deep layers of the perirhinal cortex.

Supplementary Fig. S2B

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AIp (Agranular insular area, posterior part) MBA:111 functionally connects to ENTl (Entorhinal area, lateral part) MBA:918 · Mouse

AiP stimulation evoked VSD responses in the LEC at longer latency than in the PER. Activity spread rostro-caudally from PER to LEC in control conditions and under bicuculline.

Fig. 2A,B,E,G; Fig. 3A,B,E,G

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