Whole-Brain Mapping the Direct Inputs of Dorsal and Ventral CA1 Projection Neurons

STR (Striatum) MBA:477 synapses onto CA1 (Field CA1) MBA:382 · Mouse

The striatum contributed a small share of input cells to vCA1 PNs.

Fig. 2B

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

LHA (Lateral hypothalamic area) MBA:194 synapses onto CA1 (Field CA1) MBA:382 · Mouse

The lateral hypothalamic area gave weak input to vCA1 PNs, more than to dCA1 (CSI 0.15 ± 0.02).

Fig. 8A,B

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

NDB (Diagonal band nucleus) MBA:596 synapses onto CA1 (Field CA1) MBA:382 · Mouse

The diagonal band supplied more direct input to vCA1 PNs than to dCA1 PNs (CSI 0.93 ± 0.03).

Fig. 6A,B

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

NLOT (Nucleus of the lateral olfactory tract) MBA:619 synapses onto CA1 (Field CA1) MBA:382 · Mouse

The nucleus of the lateral olfactory tract was sparsely labelled from vCA1 PNs; the value given is its share of olfactory inputs.

Fig. 9E,F

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

ENTl (Entorhinal area, lateral part) MBA:918 synapses onto CA1 (Field CA1) MBA:382 · Mouse

Lateral entorhinal input to vCA1 PNs exceeded medial entorhinal input and was stronger than to dCA1 (CSI 2.55 ± 0.33).

Fig. 5F

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

ECT (Ectorhinal area) MBA:895 synapses onto CA1 (Field CA1) MBA:382 · Mouse

The ectorhinal area was rarely labelled from vCA1 PNs, and only ipsilaterally (CSI 0.04 ± 0.02).

Fig. 7A,B

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

ENTm (Entorhinal area, medial part, dorsal zone) MBA:926 synapses onto CA1 (Field CA1) MBA:382 · Mouse

Medial entorhinal neurons were labelled from vCA1 PNs, fewer than lateral entorhinal neurons.

Fig. 5F

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

HY (Hypothalamus) MBA:1097 synapses onto CA1 (Field CA1) MBA:382 · Mouse

The hypothalamus gave weak input to vCA1 PNs, more than to dCA1 (CSI 0.38 ± 0.04).

Fig. 2B,C

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

HIP (Hippocampal region) MBA:1080 synapses onto CA1 (Field CA1) MBA:382 · Mouse

Rabies tracing from ventral CA1 projection neurons found the hippocampal region to be the largest single source of input cells.

Fig. 2A,B

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

BLA (Basolateral amygdalar nucleus) MBA:295 synapses onto CA1 (Field CA1) MBA:382 · Mouse

The basolateral nucleus supplied most of the amygdala input to vCA1 PNs; the value given is its share of amygdala input cells.

Fig. 9A-C

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

OLF (Olfactory areas) MBA:698 synapses onto CA1 (Field CA1) MBA:382 · Mouse

Olfactory areas supplied a substantial share of the input cells to vCA1 PNs.

Figs. 2B, 9E,F

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

TH (Thalamus) MBA:549 synapses onto CA1 (Field CA1) MBA:382 · Mouse

Thalamic neurons made up a minor share of the input cells to vCA1 PNs.

Fig. 2B

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

LSX (Lateral septal complex) MBA:275 synapses onto CA1 (Field CA1) MBA:382 · Mouse

The lateral septal complex gave weak input to vCA1 PNs, more than to dCA1 (CSI 0.21 ± 0.01).

Fig. 7D-F

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

ATN (Anterior group of the dorsal thalamus) MBA:239 synapses onto CA1 (Field CA1) MBA:382 · Mouse

The anterior thalamic group projected sparsely to vCA1 PNs (CSI 0.48 ± 0.19).

Fig. 8A,C

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

ECT (Ectorhinal area) MBA:895 synapses onto CA1 (Field CA1) MBA:382 · Mouse

The ectorhinal area, bilaterally and increasingly toward caudal levels, was the main isocortical input to dCA1 PNs (CSI 2.70 ± 0.55).

Fig. 7A-C

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

TR (Postpiriform transition area) MBA:566 synapses onto CA1 (Field CA1) MBA:382 · Mouse

The postpiriform transition area was a main olfactory input to vCA1 PNs; the value given is its share of olfactory inputs.

Fig. 9E,F

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

COA (Cortical amygdalar area) MBA:631 synapses onto CA1 (Field CA1) MBA:382 · Mouse

The cortical amygdalar area was the largest olfactory input to vCA1 PNs; the value given is its share of olfactory inputs.

Fig. 9E,F

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

LA (Lateral amygdalar nucleus) MBA:131 synapses onto CA1 (Field CA1) MBA:382 · Mouse

Lateral amygdala neurons gave a small share of the amygdala input to vCA1 PNs; the value given is that share.

Fig. 9A-C

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

ENT (Entorhinal area) MBA:909 synapses onto CA1 (Field CA1) MBA:382 · Mouse

A small number of ipsilateral entorhinal neurons, spread evenly along the rostrocaudal axis, were labelled from dCA1 PNs (CSI 0.29 ± 0.06).

Figs. 3B,C, 5A

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

CA2 (Field CA2) MBA:423 synapses onto CA1 (Field CA1) MBA:382 · Mouse

CA2 cells, mostly ipsilateral and caudal, were robustly labelled from vCA1 PNs, but more weakly than from dCA1 (CSI 0.76 ± 0.12).

Figs. 3, 4, 5A-C

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

PIR (Piriform area) MBA:961 synapses onto CA1 (Field CA1) MBA:382 · Mouse

Piriform cortex was a main olfactory input source to vCA1 PNs; the value given is its share of olfactory inputs.

Fig. 9E,F

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

VENT (Ventral group of the dorsal thalamus) MBA:637 synapses onto CA1 (Field CA1) MBA:382 · Mouse

The ventral thalamic group projected sparsely to vCA1 PNs (CSI 0.07 ± 0.04).

Fig. 8A,C

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

PAL (Pallidum) MBA:803 synapses onto CA1 (Field CA1) MBA:382 · Mouse

The pallidum was sparsely labelled from dCA1 PNs.

Fig. 2A,B

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

OLF (Olfactory areas) MBA:698 synapses onto CA1 (Field CA1) MBA:382 · Mouse

Olfactory areas projected to vCA1 but not to dCA1 PNs.

Fig. 2A,B

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

ENTm (Entorhinal area, medial part, dorsal zone) MBA:926 synapses onto CA1 (Field CA1) MBA:382 · Mouse

No medial entorhinal input neurons were found in the dCA1 tracing group.

Fig. 5F

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

PVT (Paraventricular nucleus of the thalamus) MBA:149 synapses onto CA1 (Field CA1) MBA:382 · Mouse

The paraventricular thalamus projected to vCA1 but not dCA1 PNs; no input cells were seen in the dCA1 group.

Fig. 8A,C

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

RE (Nucleus of reuniens) MBA:181 synapses onto CA1 (Field CA1) MBA:382 · Mouse

Nucleus reuniens neurons were labelled from vCA1 PNs (CSI 0.63 ± 0.10).

Fig. 8A,C

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

PAL (Pallidum) MBA:803 synapses onto CA1 (Field CA1) MBA:382 · Mouse

The pallidum contributed a minor share of input cells to vCA1 PNs.

Fig. 2B

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

RE (Nucleus of reuniens) MBA:181 synapses onto CA1 (Field CA1) MBA:382 · Mouse

No labelled reuniens neurons were found in the dCA1 tracing group.

Fig. 8A,C

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

ILM (Intralaminar nuclei of the dorsal thalamus) MBA:51 synapses onto CA1 (Field CA1) MBA:382 · Mouse

The intralaminar thalamic nuclei projected sparsely to vCA1 PNs (CSI 0.20 ± 0.05).

Fig. 8A,C

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

PVT (Paraventricular nucleus of the thalamus) MBA:149 synapses onto CA1 (Field CA1) MBA:382 · Mouse

Paraventricular thalamic neurons were labelled from vCA1 PNs (CSI 0.39 ± 0.06).

Fig. 8A,C

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

MED (Medial group of the dorsal thalamus) MBA:444 synapses onto CA1 (Field CA1) MBA:382 · Mouse

The medial thalamic group projected sparsely to vCA1 PNs (CSI 0.21 ± 0.07).

Fig. 8A,C

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

BLAp (Basolateral amygdalar nucleus, posterior part) MBA:311 synapses onto CA1 (Field CA1) MBA:382 · Mouse

Most BLA input cells to vCA1 PNs lay in the posterior BLA; the value given is its share of BLA input cells.

Fig. 9D

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

Isocortex MBA:315 synapses onto CA1 (Field CA1) MBA:382 · Mouse

Isocortex contributed only a very small share of input cells to vCA1 PNs.

Fig. 2B

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

BLAv (Basolateral amygdalar nucleus, ventral part) MBA:451 synapses onto CA1 (Field CA1) MBA:382 · Mouse

A minority of BLA input cells to vCA1 PNs were in the ventral BLA; the value given is its share of BLA input cells.

Fig. 9D

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

CA3 (Field CA3) MBA:463 synapses onto CA1 (Field CA1) MBA:382 · Mouse

Bilateral CA3 neurons, largely caudal, were the largest hippocampal input to vCA1 PNs (CSI 13.03 ± 0.78; share given is of hippocampal inputs).

Figs. 3, 4, 5A-C

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

sAMY (Striatum-like amygdalar nuclei) MBA:278 synapses onto CA1 (Field CA1) MBA:382 · Mouse

Striatum-like amygdalar nuclei contributed input cells to vCA1 PNs; the value given is their share of amygdala inputs.

Fig. 9A,B

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

CTXsp (Cortical subplate) MBA:703 synapses onto CA1 (Field CA1) MBA:382 · Mouse

Amygdala nuclei projected to vCA1 but not to dCA1 PNs.

Fig. 2A,B

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

LPO (Lateral preoptic area) MBA:226 synapses onto CA1 (Field CA1) MBA:382 · Mouse

The lateral preoptic area gave weak input to vCA1 PNs, more than to dCA1 (CSI 0.24 ± 0.03).

Fig. 8A,B

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

CTXsp (Cortical subplate) MBA:703 synapses onto CA1 (Field CA1) MBA:382 · Mouse

Amygdala nuclei of the cortical subplate projected only ipsilaterally to vCA1 PNs.

Figs. 2B, 9A

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

BLAa (Basolateral amygdalar nucleus, anterior part) MBA:303 synapses onto CA1 (Field CA1) MBA:382 · Mouse

Fewer BLA input cells to vCA1 PNs were in the anterior BLA; the value given is its share of BLA input cells.

Fig. 9D

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

MS (Medial septal nucleus) MBA:564 synapses onto CA1 (Field CA1) MBA:382 · Mouse

Medial septal neurons, mostly ipsilateral, were labelled from vCA1 PNs at a level similar to dCA1 (CSI 0.74 ± 0.02).

Fig. 6A-E

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

ENT (Entorhinal area) MBA:909 synapses onto CA1 (Field CA1) MBA:382 · Mouse

Bilateral entorhinal cortex was a major input to vCA1 PNs (CSI 3.4 ± 0.47), with labelled cells increasing caudally.

Figs. 3B,C, 4B,C, 5A

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

BMA (Basomedial amygdalar nucleus) MBA:319 synapses onto CA1 (Field CA1) MBA:382 · Mouse

Basomedial amygdala neurons were labelled from vCA1 PNs; the value given is their share of amygdala inputs.

Fig. 9A-C

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

PAA (Piriform-amygdalar area) MBA:788 synapses onto CA1 (Field CA1) MBA:382 · Mouse

The piriform-amygdalar area was sparsely labelled from vCA1 PNs; the value given is its share of olfactory inputs.

Fig. 9E,F

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.