Localization and connections of the tail of caudate and caudal putamen in mouse brain

VISpor (Postrhinal area) MBA:312782628 projects to CP (Caudoputamen) MBA:672 · Mouse

Tracer in PoR of a Cux2-Cre mouse strongly labeled terminals in the CaT∼.

Figs. 10E-F

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GPe (Globus pallidus, external segment) MBA:1022 projects to SNr (Substantia nigra, reticular part) MBA:381 · Mouse

GPe-restricted tracer injections strongly labeled terminals in the SNR.

Supplementary Fig. 9

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AUDp (Primary auditory area) MBA:1002 projects to CP (Caudoputamen) MBA:672 · Mouse

Primary auditory cortex neurons were labeled after caudal CP injections, more than after intermediate putamen injections.

Results 3.3; Supplementary Table 1

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MGd (Medial geniculate complex, dorsal part) MBA:1072 projects to CP (Caudoputamen) MBA:672 · Mouse

Anterograde tracer injected into dorsal MG of a Slc17a6-Cre mouse labeled terminals in the ventromedial PuC∼.

Figs. 8C-D

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AUDv (Ventral auditory area) MBA:1018 projects to CP (Caudoputamen) MBA:672 · Mouse

Ventral auditory cortex layer 5 neurons were FG-labeled after a caudal CP injection.

Fig. 7A

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VISl (Lateral visual area) MBA:409 projects to CP (Caudoputamen) MBA:672 · Mouse

Tracer injected in V2L of a Tlx3-Cre (layer 5) mouse strongly labeled terminals in the dorsolateral caudal CP (CaT∼).

Figs. 10A-B

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SSs (Supplemental somatosensory area) MBA:378 projects to CP (Caudoputamen) MBA:672 · Mouse

Layer 5 neurons of S2 were labeled after FG injections into the intermediate and rostral caudal putamen.

Figs. 4D, 5D

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PERI (Perirhinal area) MBA:922 projects to CP (Caudoputamen) MBA:672 · Mouse

Perirhinal cortex contained FG-labeled neurons, including in layers 2-4, after intermediate and rostral caudal putamen injections.

Figs. 4H, 5H

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PF (Parafascicular nucleus) MBA:930 projects to CP (Caudoputamen) MBA:672 · Mouse

PF neurons were retrogradely labeled from intermediate and caudal CP injections, with more labeling when the CaT∼ was included.

Figs. 4E, 5E; Supplementary Table 1

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PF (Parafascicular nucleus) MBA:930 projects to CP (Caudoputamen) MBA:672 · Mouse

Anterograde tracer in lateral PF labeled terminals mostly in CaT∼ and dorsal PuC∼.

Supplementary Fig. 6

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CP (Caudoputamen) MBA:672 projects to SNr (Substantia nigra, reticular part) MBA:381 · Mouse

Allen injections into dorsal PuI∼/CaT∼ in wild-type and Drd1a-Cre mice strongly labeled terminals in ventrolateral SNR.

Figs. 13D-F, 14D-E

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MOp (Primary motor area) MBA:985 projects to CP (Caudoputamen) MBA:672 · Mouse

M1 layer 5 neurons were labeled after FG injections into the intermediate and rostral caudal putamen.

Figs. 4I, 5I

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MBmot (Midbrain, motor related) MBA:323 projects to CP (Caudoputamen) MBA:672 · Mouse

Retrogradely labeled cells were present in the lateral substantia nigra after FG injections at intermediate and caudal levels of the caudoputamen.

Figs. 4B, 5B, 6E

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TEa (Temporal association areas) MBA:541 projects to CP (Caudoputamen) MBA:672 · Mouse

TeA neurons were retrogradely labeled from intermediate and caudal CP.

Figs. 4H, 5H, 6C

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CP (Caudoputamen) MBA:672 projects to MBmot (Midbrain, motor related) MBA:323 · Mouse

BDA injections into intermediate and caudal putamen labeled varicose terminals mainly in the lateral substantia nigra.

Figs. 11C, 11G, 12C, 12G; Supplementary Fig. 8E

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PTLp (Posterior parietal association areas) MBA:22 projects to CP (Caudoputamen) MBA:672 · Mouse

PPC neurons were labeled after FG injection into caudal CP involving CaT∼.

Fig. 7F

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LGd (Dorsal part of the lateral geniculate complex) MBA:170 projects to CP (Caudoputamen) MBA:672 · Mouse

No LG labeling followed intermediate putamen injections; some LG labeling followed caudal CP injections but was attributed to uptake by LG fibers passing through dorsal caudal CP.

Results 3.3

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MGm (Medial geniculate complex, medial part) MBA:1088 projects to CP (Caudoputamen) MBA:672 · Mouse

The MGM contained retrogradely labeled neurons after FG injections at all tested CP levels, more so for caudal putamen injections.

Figs. 4G, 5G, 6B

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BLA (Basolateral amygdalar nucleus) MBA:295 projects to NLOT (Nucleus of the lateral olfactory tract) MBA:619 · Mouse

Very heavy terminal labeling was found in the nucleus of the lateral olfactory tract after BL injection.

Fig. 9A

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MGv (Medial geniculate complex, ventral part) MBA:1079 projects to AUDp (Primary auditory area) MBA:1002 · Mouse

Ventral MG tracer injection produced strong terminal labeling mainly in layer 4 of Au1.

Fig. 8A

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CP (Caudoputamen) MBA:672 projects to GPe (Globus pallidus, external segment) MBA:1022 · Mouse

BDA injections into intermediate and caudal putamen and Allen injections into CaB∼/CaT∼ labeled terminals topographically in the GPe.

Figs. 11B, 11F, 12B, 12F, 13A-B, 14B

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MGv (Medial geniculate complex, ventral part) MBA:1079 projects to CP (Caudoputamen) MBA:672 · Mouse

FG injections restricted to the caudal putamen labeled neurons in the ventral medial geniculate nucleus.

Supplementary Fig. 5

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CP (Caudoputamen) MBA:672 projects to VPM (Ventral posteromedial nucleus of the thalamus) MBA:733 · Mouse

BDA striatal injections labeled terminals in VPM, but the authors could not exclude uptake by corticofugal fibers of passage and leave the projection unresolved.

Figs. 11D, 11H, 12D, 12H; Results 3.5

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CP (Caudoputamen) MBA:672 projects to GPe (Globus pallidus, external segment) MBA:1022 · Mouse

Cre-dependent tracer injections into the CP of Drd2-Cre and Penk-Cre mice labeled terminals topographically in the GPe only.

Fig. 15

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SSp (Primary somatosensory area) MBA:322 projects to CP (Caudoputamen) MBA:672 · Mouse

Primary somatosensory cortex, including barrel field, contained FG-labeled layer 5 neurons after intermediate and caudal CP injections.

Figs. 4D, 5D, 6G

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SSs (Supplemental somatosensory area) MBA:378 projects to CP (Caudoputamen) MBA:672 · Mouse

S2 afferents terminated mostly in the CaT∼ in Allen anterograde data.

Results 3.4 (data not shown)

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AI (Agranular insular area) MBA:95 projects to CP (Caudoputamen) MBA:672 · Mouse

Agranular insular neurons were retrogradely labeled from intermediate and caudal CP.

Figs. 4I, 5I, 6H

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MOs (Secondary motor area) MBA:993 projects to CP (Caudoputamen) MBA:672 · Mouse

Allen anterograde data showed M2 afferents terminating mostly in the dorsolateral caudal CP.

Results 3.4 (data not shown)

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ECT (Ectorhinal area) MBA:895 projects to CP (Caudoputamen) MBA:672 · Mouse

Ectorhinal cortex neurons were FG-labeled after intermediate and caudal CP injections.

Figs. 4H, 5H, 6C

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VTA (Ventral tegmental area) MBA:749 projects to CP (Caudoputamen) MBA:672 · Mouse

FG injections into intermediate and caudal caudoputamen produced labeled neurons in the VTA.

Figs. 4C, 5C, 6E

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LP (Lateral posterior nucleus of the thalamus) MBA:218 projects to CP (Caudoputamen) MBA:672 · Mouse

Lateral posterior thalamic neurons were labeled after FG injections into the caudal CP.

Results 3.3 (data not shown); Supplementary Table 1

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AUDd (Dorsal auditory area) MBA:1011 projects to CP (Caudoputamen) MBA:672 · Mouse

Dorsal auditory cortex neurons were retrogradely labeled from the caudal CP.

Fig. 7C

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MGv (Medial geniculate complex, ventral part) MBA:1079 projects to CP (Caudoputamen) MBA:672 · Mouse

Allen viral tracer injection into ventral MG of a Prkcd-Cre mouse gave labeled axon terminals in the medial PuC∼.

Figs. 8A-B

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GPe (Globus pallidus, external segment) MBA:1022 projects to VPM (Ventral posteromedial nucleus of the thalamus) MBA:733 · Mouse

GPe-restricted viral tracer injections produced no terminal labeling in the VPM.

Supplementary Fig. 9

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BLA (Basolateral amygdalar nucleus) MBA:295 projects to CP (Caudoputamen) MBA:672 · Mouse

BL neurons were FG-labeled from intermediate and caudal CP, with many more when injections involved CaT∼ than PuC∼ alone.

Fig. 6F; Results 3.3; Supplementary Table 1

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PIL (Posterior intralaminar thalamic nucleus) MBA:560581563 projects to CP (Caudoputamen) MBA:672 · Mouse

PIL neurons were retrogradely labeled from the intermediate and caudal putamen, with more labeling after caudal putamen injections.

Figs. 4B-C, 5B-C; Supplementary Table 1

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BLA (Basolateral amygdalar nucleus) MBA:295 projects to CP (Caudoputamen) MBA:672 · Mouse

Viral tracer injected into BL heavily labeled terminals throughout the CP of both hemispheres, notably the dorsolateral caudal CP (CaT∼) and medial PuC∼, stronger ipsilaterally.

Fig. 9

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VISpor (Postrhinal area) MBA:312782628 projects to CP (Caudoputamen) MBA:672 · Mouse

Postrhinal cortex contained retrogradely labeled neurons after caudal CP FG injection.

Results 3.3 (data not shown)

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VIS (Visual areas) MBA:669 projects to CP (Caudoputamen) MBA:672 · Mouse

Neurons in V2M and V2L were retrogradely labeled from the caudal CP.

Figs. 7C-D

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SNc (Substantia nigra, compact part) MBA:374 projects to CP (Caudoputamen) MBA:672 · Mouse

Fluoro-Gold injected into the intermediate putamen or the caudal caudoputamen retrogradely labeled many neurons in the SNC.

Figs. 4B, 5B, 6E; Supplementary Fig. 5

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SSp (Primary somatosensory area) MBA:322 projects to CP (Caudoputamen) MBA:672 · Mouse

S1 afferents terminated mostly in the CaT∼ in Allen anterograde data.

Results 3.4 (data not shown)

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ENTl (Entorhinal area, lateral part) MBA:918 projects to CP (Caudoputamen) MBA:672 · Mouse

LEC neurons were labeled after FG injections into the caudal CP, few from rostral PuC∼ and many when CaT∼ was included.

Fig. 7B; Results 3.3

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AUD (Auditory areas) MBA:247 projects to CP (Caudoputamen) MBA:672 · Mouse

Auditory cortex injection in an Emx1-Cre mouse labeled terminals heavily in both CaT∼ and PuC∼.

Figs. 10C-D

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CP (Caudoputamen) MBA:672 projects to GPi (Globus pallidus, internal segment) MBA:1031 · Mouse

In all Drd2-Cre and Penk-Cre cases with CP injections, no axon terminals were found in the GPi.

Fig. 15; Results 3.7

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MGd (Medial geniculate complex, dorsal part) MBA:1072 projects to AUDp (Primary auditory area) MBA:1002 · Mouse

Dorsal MG tracer injection labeled terminals mainly in layer 4 of Au1.

Fig. 8C

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GPe (Globus pallidus, external segment) MBA:1022 projects to PF (Parafascicular nucleus) MBA:930 · Mouse

Viral tracer injections restricted to the GPe showed strong projections to the PF.

Supplementary Fig. 9

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BLA (Basolateral amygdalar nucleus) MBA:295 projects to ACB (Nucleus accumbens) MBA:56 · Mouse

BL tracer injection produced very heavy terminal labeling in the nucleus accumbens–olfactory tubercle region.

Fig. 9A; Results 3.4

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PTLp (Posterior parietal association areas) MBA:22 projects to CP (Caudoputamen) MBA:672 · Mouse

Posterior parietal cortex afferents ended mostly in the CaT∼ in Allen anterograde data.

Results 3.4 (data not shown)

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CP (Caudoputamen) MBA:672 projects to GPi (Globus pallidus, internal segment) MBA:1031 · Mouse

Striatal tracer injections labeled terminals in the GPi, weakly after BDA in PuI∼ and strongly in dorsal GPi in Allen wild-type and Drd1a-Cre cases.

Figs. 11F, 13B, 14C; Supplementary Fig. 8G

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CP (Caudoputamen) MBA:672 projects to STN (Subthalamic nucleus) MBA:470 · Mouse

BDA injections in ventral PuI∼ gave weak terminal labeling in lateral STh, whereas Allen injections in dorsal PuI∼ and CaT∼ showed no STh labeling.

Figs. 11D, 11H, 13C

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