The projection from dorsal medial prefrontal cortex to basolateral amygdala promotes behaviors of negative emotion in rats

PL (Prelimbic area) UBERON:8440032 projects to BLA (basal amygdaloid nucleus) UBERON:0002887 · Rat

After bilateral injection of AAV5-CaMKIIa-ChR2-mCherry into dmPFC, strong mCherry-labelled axon terminals were seen in the basolateral amygdala, indicating a projection from dmPFC excitatory principal neurons to BLA.

Fig. 1A,B,D; Results, first section

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5) agrees.

PL (Prelimbic area) UBERON:8440032 projects to CEA (central amygdaloid nucleus) UBERON:0002883 · Rat

In the same animals injected with the CaMKIIa-ChR2-mCherry vector in dmPFC, no mCherry labelling was detected in the central nucleus of the amygdala, indicating that dmPFC excitatory neurons do not project there.

Fig. 1D; Results, first section

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5) agrees.