A central amygdala input to the dorsal vagal complex controls gastric motility in mice under restraint stress

CEA (Central amygdalar nucleus) MBA:536 projects to MY (Medulla) MBA:354 · Mouse

A Cre-dependent AAV expressing mCherry was injected unilaterally into the central amygdala of GAD2-Cre mice; three weeks later labelled somata were confined to the CeA while many labelled fibres/terminals appeared in the dorsal vagal complex, indicating an axonal projection from CeA GABAergic cells to the DVC.

Fig. 4A–C; Results, "An inhibitory pathway from CeAGABA to DVC"

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5) agrees.

CEA (Central amygdalar nucleus) MBA:536 functionally connects to MY (Medulla) MBA:354 · Mouse

In brain slices from GAD2-Cre mice expressing ChR2 in CeA GABAergic neurons, brief blue-light pulses over CeA terminals in the dorsal vagal complex consistently evoked inhibitory postsynaptic currents in DVC neurons, and these currents were abolished by the GABA-A receptor blocker picrotoxin, showing a GABAergic inhibitory functional connection.

Fig. 4D–F; Results, "An inhibitory pathway from CeAGABA to DVC"

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5) agrees.