Control of innate olfactory valence by segregated cortical amygdala circuits

COApl (Cortical amygdalar area, posterior part, lateral zone) MBA:655 projects to OT (Olfactory tubercle) MBA:754 · Mouse

Anterograde tracing from plCoA labelled terminals in the olfactory tubercle. Collateral mapping showed that NAc-projecting plCoA neurons send strong collaterals to OT.

Fig. 6A–D, 6S–T

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

COApl (Cortical amygdalar area, posterior part, lateral zone) MBA:655 projects to ACB (Nucleus accumbens) MBA:56 · Mouse

Retrobeads injected into the nucleus accumbens labelled plCoA neurons, mostly in the posterior zone. In middle plCoA, these cells were largely VGluT1-positive.

Fig. 6E–H; Fig. 6—figure supplement 2

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

COApl (Cortical amygdalar area, posterior part, lateral zone) MBA:655 projects to MEA (Medial amygdalar nucleus) MBA:403 · Mouse

Red retrobeads injected into the medial amygdala labelled plCoA neurons, most of them in the anterior zone. In middle plCoA, most bead-labelled cells were VGluT2-positive.

Fig. 6E–H; Fig. 6—figure supplement 2

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

COApl (Cortical amygdalar area, posterior part, lateral zone) MBA:655 projects to MEA (Medial amygdalar nucleus) MBA:403 · Mouse

Synaptophysin-tagged anterograde labelling from middle plCoA showed terminals in the medial amygdala. Dual-color tracing found this projection densest from anterior plCoA, and Cre-dependent tracing showed both VGluT2+ and VGluT1+ plCoA neurons reach MeA, with a VGluT2+ bias.

Fig. 6A–D, 6I–L, 6M–P

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

COApl (Cortical amygdalar area, posterior part, lateral zone) MBA:655 projects to BST (Bed nuclei of the stria terminalis) MBA:351 · Mouse

Anterograde synaptophysin-EGFP tracing from middle plCoA labelled presynaptic terminals in the BNST.

Fig. 6A–D

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

COApl (Cortical amygdalar area, posterior part, lateral zone) MBA:655 projects to HATA (Hippocampo-amygdalar transition area) MBA:589508447 · Mouse

Long-range synaptophysin-labelled projections from plCoA were seen in the amygdalo-hippocampal transition area.

Fig. 6A–D

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

COApl (Cortical amygdalar area, posterior part, lateral zone) MBA:655 projects to PIR (Piriform area) MBA:961 · Mouse

Anterograde terminal labelling from plCoA appeared in the piriform cortex, one of the olfactory targets noted as a primary output.

Fig. 6A–D

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

COApl (Cortical amygdalar area, posterior part, lateral zone) MBA:655 projects to COApm (Cortical amygdalar area, posterior part, medial zone) MBA:663 · Mouse

A retrograde-Cre plus Cre-dependent anterograde strategy labelled the outputs of MeA-projecting plCoA neurons. Their strongest collateral target was the posteromedial cortical amygdala.

Fig. 6Q–T

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

COApl (Cortical amygdalar area, posterior part, lateral zone) MBA:655 projects to ACB (Nucleus accumbens) MBA:56 · Mouse

Anterograde terminal labelling from plCoA covered nucleus accumbens core and shell without spatial restriction. The projection was densest from posterior plCoA and came mainly from VGluT1+ neurons.

Fig. 6A–D, 6I–L, 6M–P

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.