Altered corticolimbic connectivity reveals sex-specific adolescent outcomes in a rat model of early life adversity

BLA (basal amygdaloid nucleus) UBERON:0002887 projects to ILA (Infralimbic area) UBERON:8440033 · Rat

BDA-labelled fibres from the BLA were quantified stereologically in infralimbic layers 2 and 5. Innervation of layer 2 was increased after early-life adversity at PD28 in females and at PD38 in males.

Fig. 2B; Results, Study 1, IL innervation

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

BLA (basal amygdaloid nucleus) UBERON:0002887 projects to PL (Prelimbic area) UBERON:8440032 · Rat

After BDA was injected into the BLA of juvenile and adolescent rats, labelled BLA axons were found in prelimbic cortex layers 2 and 5. Stereology gave total terminal length, and this was elevated by early-life adversity at PD28 and PD48 in females and at PD38 in males.

Fig. 2A; Results, Study 1, PL innervation

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.