Subcortico-amygdala pathway processes innate and learned threats

MG (Medial geniculate complex) MBA:475 projects to BLA (Basolateral amygdalar nucleus) MBA:295 · Mouse

GCaMP7s was expressed in the medial geniculate/LT and an optic fiber was placed over the BLA. Axon terminals of these thalamic neurons in the BLA showed calcium signals evoked by looming stimuli, tones and footshocks.

Fig. 3A-C

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) disagrees. “Fig. 3A-C shows GCaMP7s fiber photometry of thalamic axon terminals, a calcium-imaging method rather than anterograde tracing, and the panels show only the injection and fiber placement.”

TH (Thalamus) MBA:549 projects to ZI (Zona incerta) MBA:797 · Mouse

mCherry-labelled axons from virus-expressing LT neurons were seen in the zona incerta.

Fig. 4—figure supplement 1C

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

TH (Thalamus) MBA:549 projects to BLA (Basolateral amygdalar nucleus) MBA:295 · Mouse

Retrograde AAV-Cre injected into the BLA, combined with Cre-dependent GFP in the LT, labelled BLA-projecting neurons. The labelled cells were largely restricted to the LT.

Fig. 2A-F

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

TH (Thalamus) MBA:549 functionally connects to BLA (Basolateral amygdalar nucleus) MBA:295 · Mouse

In anesthetized mice, light pulses delivered to ChrimsonR-expressing LT axons evoked field EPSPs recorded in the BLA. These responses were reduced by CNO when hM4Di was expressed in either the BLA or the LT.

Fig. 1A-B; Fig. 4C-D

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

TH (Thalamus) MBA:549 projects to AUD (Auditory areas) MBA:247 · Mouse

LT expression of hM4Di-mCherry produced axonal labelling in the auditory cortex.

Fig. 4—figure supplement 1C

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

TH (Thalamus) MBA:549 projects to TEa (Temporal association areas) MBA:541 · Mouse

After hM4Di-mCherry was expressed in the LT, mCherry-labelled axons were seen in the temporal associative cortex.

Fig. 4—figure supplement 1C

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.