Periaqueductal gray activates antipredatory neural responses in the amygdala of foraging rats

PAG (Periaqueductal gray) UBERON:0003040 functionally connects to BLA (basal amygdaloid nucleus) UBERON:0002887 · Rat

Blue-light activation of ChR2-expressing CaMKII neurons in the dPAG of freely foraging rats raised the firing of a subset of BLA units recorded with tetrodes; the authors judge the route likely indirect from latencies and anatomy.

Fig. 3E, 3H-L; Figure 3—figure supplement 1B-C

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PAG (Periaqueductal gray) UBERON:0003040 projects to MTN (Midline group of the dorsal thalamus) UBERON:0002705 · Rat

After AAV-CaMKII-EYFP injection into the dPAG, labelled axon terminals were seen mainly in the midline nuclei of the thalamus, which the authors describe as strong terminal expression.

Fig. 4D

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PAG (Periaqueductal gray) UBERON:0003040 projects to PVT (Paraventricular nucleus of the thalamus) UBERON:0001920 · Rat

EYFP-labelled terminals arising from the AAV-infected dPAG cell bodies were present in the PVT, where they overlapped with CTB-labelled and c-Fos-positive neurons.

Fig. 4D, 4G

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PVT (Paraventricular nucleus of the thalamus) UBERON:0001920 projects to BLA (basal amygdaloid nucleus) UBERON:0002887 · Rat

Injecting cholera toxin B into the BLA retrogradely labelled PVT neurons, and a larger share of these labelled cells expressed c-Fos after a robot predator encounter.

Fig. 4G-H; Figure 4—figure supplement 1

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