Cue- versus reward-encoding basolateral amygdala projections to nucleus accumbens

Posterior BLA Ppp1r1b-expressing principal neurons nt-w8taxnhqmz projects to ACB (Nucleus accumbens) MBA:56 · Mouse

Cre-dependent ChR2-eYFP in Cartpt-Cre (Ppp1r1b) BLA neurons produced labelled somata in the BLA and extensive labelled axon fibres in the accumbens core and shell.

Fig. 1O–U

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5) agrees.

Anterior BLA Rspo2-expressing principal neurons nt-56rbnwx5rb projects to ACB (Nucleus accumbens) MBA:56 · Mouse

Cre-dependent ChR2-eYFP expressed in Rspo2-Cre BLA neurons labelled somata in the BLA and axonal fibres in both the core and shell of the nucleus accumbens eight weeks after injection.

Fig. 1C–I

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5) agrees.

Posterior BLA Ppp1r1b-expressing principal neurons nt-w8taxnhqmz functionally connects to ACB (Nucleus accumbens) MBA:56 · Mouse

Optogenetic activation of Ppp1r1b axon terminals produced EPSCs in D2 (tdTomato-negative) medium spiny neurons that were blocked by NBQX and D-AP5.

Fig. 1V–X, 1Y–Z

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5) agrees.

BLA (Basolateral amygdalar nucleus) MBA:295 functionally connects to ACB (Nucleus accumbens) MBA:56 · Mouse

In accumbens slices containing SSFO-expressing BLA terminals, a 473 nm light train raised the frequency of spontaneous EPSCs in medium spiny neurons without changing their amplitude, and 590 nm light reversed the effect, showing a presynaptic BLA glutamatergic input to accumbens neurons.

Fig. 3C–D

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5) agrees.

Anterior BLA Rspo2-expressing principal neurons nt-56rbnwx5rb functionally connects to ACB (Nucleus accumbens) MBA:56 · Mouse

Optogenetic activation of Rspo2 axon terminals in the accumbens evoked fast glutamatergic EPSCs in tdTomato-negative (D2) medium spiny neurons, which were blocked by NBQX plus D-AP5.

Fig. 1J–L, 1Y–Z

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5) agrees.