Non-Hebbian plasticity transforms transient experiences into lasting memories

AUD (Auditory areas) MBA:247 projects to LA (Lateral amygdalar nucleus) MBA:131 · Mouse

AAV-oChIEF-tdTomato injected into the LA-projecting auditory/associative cortical region produced labelled axons in the lateral amygdala.

Figure 3—figure supplement 1a

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TH (Thalamus) MBA:549 functionally connects to LA (Lateral amygdalar nucleus) MBA:131 · Mouse

In amygdala slices, optical activation of ChrimsonR-expressing thalamic axons evoked AMPA receptor-mediated synaptic currents in lateral amygdala neurons recorded in whole-cell mode (with GABA-A and NMDA receptors blocked); co-illumination with yellow light suppressed these responses.

Figure 2a-c

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AUD (Auditory areas) MBA:247 functionally connects to LA (Lateral amygdalar nucleus) MBA:131 · Mouse

In lateral amygdala slices, electrical stimulation of external capsule (cortical) fibres evoked EPSPs in putative pyramidal neurons; strong tetanic stimulation of this pathway stabilised potentiation of the converging thalamic pathway.

Figure 5d-f

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TH (Thalamus) MBA:549 projects to LA (Lateral amygdalar nucleus) MBA:131 · Mouse

AAV expressing oChIEF-tdTomato injected in the lateral thalamus produced labelled axons in the lateral amygdala, visualised in coronal sections.

Figure 1—figure supplement 1a

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TH (Thalamus) MBA:549 functionally connects to LA (Lateral amygdalar nucleus) MBA:131 · Mouse

Blue light pulses on oChIEF- or ChrimsonR-expressing thalamic axons evoked field EPSPs recorded in the lateral amygdala of anesthetized mice; these responses were potentiated by high-frequency optical stimulation and were abolished by the AMPA receptor blocker NBQX and by TTX, showing a glutamatergic synaptic connection.

Figure 1c,d; Figure 2f

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AUD (Auditory areas) MBA:247 functionally connects to LA (Lateral amygdalar nucleus) MBA:131 · Mouse

Optical activation of oChIEF-expressing auditory/associative cortical axons evoked field EPSPs in the lateral amygdala of anesthetized and freely moving mice, which were potentiated by high-frequency stimulation of those same cortical fibres.

Figure 4i,j (middle); Figure 5b

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TH (Thalamus) MBA:549 functionally connects to LA (Lateral amygdalar nucleus) MBA:131 · Mouse

Electrical stimulation of internal capsule (thalamic) afferent fibres in lateral amygdala slices evoked EPSPs in putative pyramidal cells, and weak tetanic stimulation produced a transient potentiation of these responses.

Figure 5d-f

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TH (Thalamus) MBA:549 projects to LA (Lateral amygdalar nucleus) MBA:131 · Mouse

AAV-GCaMP7s injected into the lateral thalamus labelled axons in the lateral amygdala, where footshock-locked calcium signals were recorded from these terminals by fiber photometry.

Figure 4a; Figure 4—figure supplement 1a

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