clm-07rvxvy8st
CEA (central amygdaloid nucleus) functionally connects to PAG (Periaqueductal gray)
All claims for this connection- Species
- Rat
- Result
- present
- Method
- optogenetic circuit mapping
- Sign
- unknown
- Evidence
- CeA ChR2 stimulation was associated with lower Fos in ventrolateral periaqueductal gray: more than 200% reduction below normal tissue baseline in reward-pursuing rats, and markedly lower counts than in eYFP controls (which showed over 400% elevation) in the shock-rod situation, so CeA activation changed PAG activity in the negative direction.
- Source
The central amygdala recruits mesocorticolimbic circuitry for pursuit of reward or pain
Nature Communications, 2020
DOI 10.1038/s41467-020-16407-1 · PubMed 32483118 · PMC7264246, Results, 'Shock-rod attraction activates mesocorticolimbic circuity'; Fig. 5; Supplementary Table 1Licence: CC-BY-4.0
- Named in the paper
- “central nucleus of amygdala (CeA)” and “ventrolateral periaqueductal gray (PAG)”
- Made by
- an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
- Checked by
a second AI model (claude-opus-5) agrees, 2026-10-09
“Text reports Fos reduction in ventrolateral PAG with CeA ChR2 and >400% higher PAG Fos in eYFP controls, with PAG significant in Fig. 5.”
- Status
proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.