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AI (Agranular insular area) projects to ACB (Nucleus accumbens)

All claims for this connection
Species
Rat
Result
present
Method
retrograde tracer
Sign
unknown
Evidence
Retrograde AAV2-retro tracer in the accumbens core labelled neurons concentrated in dorsal and ventral agranular anterior insula (layers II and V), representing 64% of the labelled accumbens-projecting insular neurons; retrograde Cre injected into the core also drove projection-specific DREADD expression in insular neurons.
Measurements
  • fraction of labelled neurons: 0.64
Source

Chemogenetic Stimulation and Silencing of the Insula, Amygdala, Nucleus Accumbens, and Their Connections Differentially Modulate Alcohol Drinking in Rats

Frontiers in Behavioral Neuroscience, 2020

DOI 10.3389/fnbeh.2020.580849 · PubMed 33328918 · PMC7671963, Figs. 5D–F; Fig. 4C

Licence: CC-BY-4.0

Named in the paper
“agranular insula (AID, AIV)” and “nucleus accumbens core (AcbC)”
Made by
an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-10
Checked by

a second AI model (claude-opus-5) agrees, 2026-10-10

“Paper's retrograde AAV2-retro tracing reports 64% of labelled accumbens-projecting insular neurons in agranular insula projecting to core.”

Status

proposed

Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.