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AI (Agranular insular area) projects to ACB (Nucleus accumbens)

2 claims from 1 source: 2 found, 0 tested and absent, 0 ambiguous. Evidence: retrograde tracer.

The claims behind it

clm-12j8rvw7vypresentretrograde tracerproposed

Retrograde AAV2-retro tracer in the accumbens core labelled neurons concentrated in dorsal and ventral agranular anterior insula (layers II and V), representing 64% of the labelled accumbens-projecting insular neurons; retrograde Cre injected into the core also drove projection-specific DREADD expression in insular neurons.

DOI 10.3389/fnbeh.2020.580849 · PubMed 33328918 · PMC7671963, Figs. 5D–F; Fig. 4C

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5) agrees.

clm-ycdkvvnbpfpresentretrograde tracerproposed

A retrograde AAV2-retro vector injected into the accumbens shell labelled anterior agranular insular neurons with a distribution similar to the core-projecting population; shell-projecting cells comprised 29% of the labelled neurons.

DOI 10.3389/fnbeh.2020.580849 · PubMed 33328918 · PMC7671963, Figs. 5D–F

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5) agrees.