clm-13s11tn7g6

BLA glutamatergic principal neurons functionally connects to CA3 (Field CA3)

Species: Mouse
Result: present
Method: optogenetic circuit mapping
Sign: excitatory
Evidence: After expressing ChR2 under the CaMKIIα promoter in BLA, blue light evoked EPSCs in dCA3 neurons recorded in slices; the responses persisted with TTX and 4-AP (monosynaptic) and were abolished by the AMPA receptor blocker DNQX, indicating a direct glutamatergic BLA-to-dCA3 connection.
Source: ERK-dependent hyperexcitability of BLA neurons projecting to dCA3 underlies social dysfunction in a male mouse model of fragile X syndrome
eBioMedicine, 2026
DOI 10.1016/j.ebiom.2026.106478 · PubMed 42700720 · PMC13572171, Fig. 1J–L
Licence: CC-BY-NC-4.0
Named in the paper: “BLA CaMKIIα+ neurons” and “dCA3”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
Checked by: a second AI model (claude-opus-5) agrees, 2026-10-09
“Slice ChR2 photostimulation of BLA gave TTX/4-AP-resistant, DNQX-sensitive EPSCs in dCA3, supporting a monosynaptic excitatory connection.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.