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Isocortex projects to BLA (Basolateral amygdalar nucleus)

Species: Mouse
Result: present
Method: anterograde tracer
Sign: unknown
Evidence: An AAV expressing tdTomato was injected into the mPFC of adult female mice, and labelled axon terminals with branches and synaptic boutons were traced in the BLA. Branching and bouton density were higher in Pten+/− than in wild-type mice.
Source: Hyperconnectivity of prefrontal cortex to amygdala projections in a mouse model of macrocephaly/autism syndrome
Nature Communications, 2016
DOI 10.1038/ncomms13421 · PubMed 27845329 · PMC5116076, Fig. 3a–e; Fig. 5c–f
Licence: CC-BY-4.0
Named in the paper: “medial prefrontal cortex (mPFC)” and “basolateral amygdala (BLA)”
Made by: an AI model reading the paper (claude-opus-5-5, extract@0.3.0), 2026-10-09
Checked by: a second AI model (claude-opus-5-5) disagrees, 2026-10-09
“The AAV-tdTomato tracing supports mPFC to BLA, but the subject is mapped to the whole isocortex, which is broader than the mPFC the paper means.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.