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AI (Agranular insular area) synapses onto BLA glutamatergic principal neurons

Species: Mouse
Result: present
Method: transsynaptic tracer
Sign: excitatory
Strength: strong
Evidence: Cre-dependent helper viruses plus EnvA-pseudotyped rabies virus in the BLA of CaMKII-Cre mice produced abundant EGFP-labelled presynaptic neurons in the insular cortex; these input neurons were largely immunopositive for glutamate and rarely for GABA.
Source: Distinct basolateral amygdala excitatory inputs mediate the somatosensory and aversive-affective components of pain
Journal of Biological Chemistry, 2022
DOI 10.1016/j.jbc.2022.102207 · PubMed 35772494 · PMC9304789, Fig. 4, A–E, I
Licence: CC-BY-4.0
Named in the paper: “insular cortex (IC)” and “BLAGlu neurons”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
Checked by: a second AI model (claude-opus-5) agrees, 2026-10-09
“Fig. 4A–E and I show abundant rabies-labelled, glutamate-positive IC input neurons to BLA glutamatergic cells.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.