clm-20p6v6c0wd
CEA corticotropin-releasing hormone-expressing neurons synapses onto PGRNl (Paragigantocellular reticular nucleus, lateral part)
All claims for this connection- Species
- Mouse
- Result
- present
- Method
- transsynaptic tracer
- Sign
- unknown
- Evidence
- Cre-dependent helper AAVs plus a Dbh-Cre virus were placed in the LPGi and then pseudotyped, glycoprotein-deleted rabies virus was injected at the same site; retrogradely labelled starter-connected neurons appeared in the CeM, and most of these labelled CeM cells were immunopositive for CRH, indicating a direct monosynaptic input from CeM CRH cells onto LPGi catecholaminergic neurons.
- Source
A brain-tumor neural circuit controls breast cancer progression in mice
Journal of Clinical Investigation, 2023
DOI 10.1172/jci167725 · PubMed 37847562 · PMC10721160, Fig. 7A-DLicence: CC-BY-4.0
- Named in the paper
- “CeMCRH neurons” and “LPGi (lateral paragigantocellular nucleus)”
- Made by
- an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
- Checked by
a second AI model (claude-opus-5) agrees, 2026-10-09
“Fig. 7A-D shows RV-based monosynaptic retrograde tracing from Dbh-Cre LPGi neurons labeling CRH-positive CeM neurons in mice, matching direction and result.”
- Status
proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.