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AI (Agranular insular area) projects to MD (Mediodorsal nucleus of thalamus)
All claims for this connection- Species
- Mouse
- Result
- present
- Method
- retrograde tracer
- Sign
- unknown
- Evidence
- Alexa Fluor 594-conjugated CTB injected into the mediodorsal thalamus retrogradely labelled aIC neurons, mainly in deep layers (about layer 6). None of these cells were also labelled by the amygdala tracer. They outnumbered the amygdala-projecting aIC cells.
- Source
Bidirectional fear modulation by discrete anterior insular circuits in male mice
eLife, 2024
DOI 10.7554/elife.95821 · PubMed 39088250 · PMC11293866, Fig. 4A-E; Figure 4—figure supplement 1Licence: CC-BY-4.0
- Named in the paper
- “anterior insular cortex (aIC)” and “medial dorsal thalamus”
- Made by
- an AI model reading the paper (claude-opus-5-5, extract@0.3.0), 2026-10-10
- Checked by
a second AI model (claude-opus-5-5) agrees, 2026-10-10
“The Fig. 4 CTB-594 thalamic injections labelled deep-layer aIC neurons that did not overlap with amygdala-projecting cells and outnumbered them, all in mice.”
- Status
proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.