clm-2crsc24ryf

LC (Locus ceruleus) functionally connects to BLA (basal amygdaloid nucleus)

Species: Rat
Result: present
Method: optogenetic circuit mapping
Sign: modulatory
Evidence: Optogenetic stimulation of locus coeruleus neurons redistributed which odor-activated basolateral amygdala neurons expressed cFos: 10-Hz phasic light favoured accumbens-projecting cells while 25-Hz tonic light favoured central-amygdala-projecting cells, with total cFos counts unchanged. Light alone without odor did not change BLA cFos patterns, and intra-BLA α- and β-adrenoceptor antagonists abolished the conditioned odor preference and aversion driven by these LC patterns, indicating a noradrenergic modulatory action.
Source: Locus Coeruleus Activation Patterns Differentially Modulate Odor Discrimination Learning and Odor Valence in Rats
Cerebral Cortex Communications, 2021
DOI 10.1093/texcom/tgab026 · PubMed 34296171 · PMC8152946, Fig. 7B–F; Fig. 6C,D; Supplementary Fig. S5
Licence: CC-BY-4.0
Named in the paper: “LC” and “BLA”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
Checked by: a second AI model (claude-opus-5) agrees, 2026-10-09
“Paper's Fig. 7 cFos/CTB redistribution plus intra-BLA adrenoceptor blockade support a modulatory LC-to-BLA functional link in rats.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.