Rat

LC (Locus ceruleus) functionally connects to BLA (basal amygdaloid nucleus)

1 claim from 1 source: 1 found, 0 tested and absent, 0 ambiguous. Evidence: optogenetic circuit mapping.

The claims behind it

clm-2crsc24ryfpresentoptogenetic circuit mappingproposed

Optogenetic stimulation of locus coeruleus neurons redistributed which odor-activated basolateral amygdala neurons expressed cFos: 10-Hz phasic light favoured accumbens-projecting cells while 25-Hz tonic light favoured central-amygdala-projecting cells, with total cFos counts unchanged. Light alone without odor did not change BLA cFos patterns, and intra-BLA α- and β-adrenoceptor antagonists abolished the conditioned odor preference and aversion driven by these LC patterns, indicating a noradrenergic modulatory action.

DOI 10.1093/texcom/tgab026 · PubMed 34296171 · PMC8152946, Fig. 7B–F; Fig. 6C,D; Supplementary Fig. S5

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