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LHA (Lateral hypothalamic area) functionally connects to PVH (Paraventricular hypothalamic nucleus)

Species: Mouse
Result: present
Method: optogenetic circuit mapping
Sign: excitatory
Evidence: Photostimulating channelrhodopsin-expressing LHA terminals evoked excitatory postsynaptic currents in PVN oxytocin neurons that were blocked by TTX and rescued by 4-AP, indicating a monosynaptic excitatory input; the same stimulation in vivo also raised the PVN OXT1.7 sensor signal.
Source: Distinct projections of PVN oxytocin neurons regulate the divergent defensive behaviors in response to social threat
Science Advances, 2026
DOI 10.1126/sciadv.aeb0400 · PubMed 42341137 · PMC13292991, fig. S4, E to L
Named in the paper: “LHA” and “PVN OXT neurons”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
Checked by: a second AI model (claude-opus-5) agrees, 2026-10-09
“Opto-evoked EPSCs in PVN OXT neurons, TTX-blocked/4-AP-restored, plus OXT release, support monosynaptic excitatory LHA input.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.