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AI (Agranular insular area) projects to ACB (Nucleus accumbens)

Species: Mouse
Result: present
Method: retrograde tracer
Sign: unknown
Evidence: Retrograde virus injected into the nucleus accumbens labelled a distinct set of insular cortex neurons, concentrated in layer 5 with additional cells in layer 6, with little overlap with amygdala-projecting IC neurons.
Source: Insular cortical circuits as an executive gateway to decipher threat or extinction memory via distinct subcortical pathways
Nature Communications, 2022
DOI 10.1038/s41467-022-33241-9 · PubMed 36130959 · PMC9492683, Supplementary Fig. 5a–e
Licence: CC-BY-4.0
Named in the paper: “IC” and “NAc”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
Checked by: a second AI model (claude-opus-5) agrees, 2026-10-09
“Retrograde virus from NAc labeled a separate IC population enriched in layers 5 and 6.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.