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BLA (Basolateral amygdalar nucleus) functionally connects to PL5 (Prelimbic area, layer 5)

Species: Mouse
Result: present
Method: optogenetic circuit mapping
Sign: unknown
Evidence: Blue-light stimulation of ChR2-expressing BLA axons in slices evoked both EPSCs (at -70 mV) and IPSCs (at +10 mV) in PL layer 5 cortico-PAG neurons; the E/I ratio was reduced after spared nerve injury.
Source: Peripheral nerve injury reduces the excitation-inhibition balance of basolateral amygdala inputs to prelimbic pyramidal neurons projecting to the periaqueductal gray
Molecular Brain, 2020
DOI 10.1186/s13041-020-00638-w · PubMed 32600466 · PMC7325111, Fig. 1f-h, m, n
Licence: CC-BY-4.0
Named in the paper: “basolateral amygdala (BLA)” and “layer 5 (L5) CP neurons in PL cortex”
Made by: an AI model reading the paper (claude-opus-5-5, extract@0.3.0), 2026-10-09
Checked by: a second AI model (claude-opus-5-5) agrees, 2026-10-09
“Light-evoked EPSCs and IPSCs were recorded in PL L5 CP neurons, with a lower E/I ratio after SNI.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.