clm-4tbt8731q0

PL (Prelimbic area) functionally connects to BLA glutamatergic principal neurons

Species: Mouse
Result: present
Method: optogenetic circuit mapping
Sign: excitatory
Evidence: Blue-light stimulation of ChR2-expressing mPFC axons in BLA slices evoked EPSCs in BLA pyramidal neurons (about 100-200 pA, mean ~170-180 pA) that were abolished by the AMPA receptor antagonist DNQX, identifying a glutamatergic mPFC-to-BLA synaptic input; paired-pulse responses and AMPA/NMDA ratios were also measured at this input.
Source: Memory retrieval in addiction: a role for miR-105-mediated regulation of D1 receptors in mPFC neurons projecting to the basolateral amygdala
BMC Biology, 2017
DOI 10.1186/s12915-017-0467-2 · PubMed 29282124 · PMC5745965, Fig. 7a (right panel), Fig. 7b,c; Fig. 8
Named in the paper: “mPFC” and “pyramidal cells of the BLA”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
Checked by: a second AI model (claude-opus-5) agrees, 2026-10-09
“ChR2 stimulation of mPFC fibers evoked DNQX-sensitive EPSCs in mouse BLA pyramidal cells, an excitatory functional connection.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.