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PL (Prelimbic area) projects to PVH (Paraventricular hypothalamic nucleus)

Species: Mouse
Result: present
Method: retrograde tracer
Sign: unknown
Evidence: After bilateral injection of a Cre-dependent retrograde AAV (AAVrg-hSyn-DIO-mCherry) into the PVN of Emx1-Cre mice, retrogradely labelled cortical neurons were found in the prelimbic cortex, indicating prelimbic projections to the PVN.
Source: Conditional deletion of Cc2d1a increases irritability-like behavior by decreasing oxytocin expression via the prelimbic-hypothalamic pathway
Journal of Biomedical Science, 2026
DOI 10.1186/s12929-026-01263-w · PubMed 42231358 · PMC13227712, Fig. 6A, B
Licence: CC-BY-4.0
Named in the paper: “PrL” and “PVN”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
Checked by: a second AI model (claude-opus-5) agrees, 2026-10-09
“Retrograde AAV in PVN of Emx1-Cre mice labeled PrL neurons, as stated in Fig. 6A,B.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.