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AI (Agranular insular area) projects to ACB (Nucleus accumbens)

Species: Mouse
Result: present
Method: anterograde tracer
Sign: unknown
Evidence: Synaptophysin-tdTomato labelling of IC neurons tagged during extinction learning revealed axonal boutons preferentially in the nucleus accumbens rather than the central amygdala.
Source: Insular cortical circuits as an executive gateway to decipher threat or extinction memory via distinct subcortical pathways
Nature Communications, 2022
DOI 10.1038/s41467-022-33241-9 · PubMed 36130959 · PMC9492683, Fig. 3g–i; Supplementary Fig. 4
Licence: CC-BY-4.0
Named in the paper: “IC (extinction-memory ensembles)” and “NAc”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
Checked by: a second AI model (claude-opus-5) agrees, 2026-10-09
“Synaptophysin-tdTomato from extinction-tagged IC neurons showed preferential NAc boutons.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.