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PL (Prelimbic area) functionally connects to CP (Caudoputamen)
All claims for this connection- Species
- Mouse
- Result
- present
- Method
- optogenetic circuit mapping
- Sign
- excitatory
- Evidence
- ChR2 expressed in prelimbic CaMKIIα neurons and blue-light stimulation of their terminals in the dorsal striatum increased grooming and produced social novelty deficits without affecting open-field anxiety measures; optogenetic silencing of the same terminals rescued these behaviours in Tmem74-/- mice, indicating a functional glutamatergic PL to dorsal striatum projection.
- Source
Divergent projections of the prelimbic cortex mediate autism- and anxiety-like behaviors
Molecular Psychiatry, 2023
DOI 10.1038/s41380-023-01954-y · PubMed 36690791 · PMC10611563, Fig. 4c–g; Supplementary Fig. 4Licence: CC-BY-4.0
- Named in the paper
- “PL” and “dSTR”
- Made by
- an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
- Checked by
a second AI model (claude-opus-5) agrees, 2026-10-09
“Optogenetic activation and suppression of PL terminals in dSTR produced/rescued autism-like behaviors without anxiety effects, as stated.”
- Status
proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.