Mouse

PL (Prelimbic area) functionally connects to CP (Caudoputamen)

1 claim from 1 source: 1 found, 0 tested and absent, 0 ambiguous. Evidence: optogenetic circuit mapping.

The claims behind it

clm-5jdkv6qpynpresentoptogenetic circuit mappingproposed

ChR2 expressed in prelimbic CaMKIIα neurons and blue-light stimulation of their terminals in the dorsal striatum increased grooming and produced social novelty deficits without affecting open-field anxiety measures; optogenetic silencing of the same terminals rescued these behaviours in Tmem74-/- mice, indicating a functional glutamatergic PL to dorsal striatum projection.

DOI 10.1038/s41380-023-01954-y · PubMed 36690791 · PMC10611563, Fig. 4c–g; Supplementary Fig. 4

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