clm-6fmpd2t7r2
PB (Parabrachial nucleus) functionally connects to VPMpc (Ventral posteromedial nucleus of the thalamus, parvicellular part)
All claims for this connection- Species
- Mouse
- Result
- present
- Method
- optogenetic circuit mapping
- Sign
- excitatory
- Evidence
- Optogenetic stimulation of CGRP parabrachial terminals in slices from CalcaFLPo::Oprm1Cre mice evoked EPSCs in almost all recorded Oprm1 VPMpc neurons (41 of 43). The responses were blocked by AMPA and NMDA receptor antagonists and were restored by 4AP after TTX.
- Measurements
- connection probability: 0.9535, n = 43
- Source
Gustatory thalamic neurons mediate aversive behaviors
Nature Communications, 2025
DOI 10.1038/s41467-025-63464-5 · PubMed 41006304 · PMC12475432, Fig. 1i–m; Supplementary Fig. 3Licence: CC-BY-4.0
- Named in the paper
- “CGRPPBN neurons” and “OPRM1VPMpc neurons”
- Made by
- an AI model reading the paper (claude-opus-5-5, extract@0.3.0), 2026-10-09
- Checked by
a second AI model (claude-opus-5-5) agrees, 2026-10-09
“The paper reports light-evoked EPSCs in 41 of 43 Oprm1 VPMpc neurons, abolished by NBQX/APV and restored by 4AP after TTX, so the input is excitatory and monosynaptic.”
- Status
proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.